Evidence map›Paper›PMID 38025271›Full record

ArticleBrain communications2023

Dorsal subthalamic nucleus targeting in deep brain stimulation: microelectrode recording versus 7-Tesla connectivity.

Naomi I Kremer, Mark J Roberts, Wouter V Potters, José Dilai, Varvara Mathiopoulou, Niels Rijks, Gea Drost, Teus van Laar, J Marc C van Dijk, Martijn Beudel and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Naomi I KremerDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.ORCID https://orcid.org/0000-0002-7818-0318
Mark J RobertsFaculty of Psychology and Neuroscience, Maastricht University, Maastricht 6211 LK, The Netherlands.ORCID https://orcid.org/0000-0001-7513-1281
Wouter V PottersDepartment of Neurology and Clinical Neurophysiology, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
José DilaiDepartment of Neurology and Clinical Neurophysiology, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Varvara MathiopoulouDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Niels RijksDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Gea DrostDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.
Teus van LaarDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.
J Marc C van DijkDepartment of Neurosurgery, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, The Netherlands.
Martijn BeudelDepartment of Neurology and Clinical Neurophysiology, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Rob M A de BieDepartment of Neurology and Clinical Neurophysiology, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Pepijn van den MunckhofDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Marcus L F JanssenDepartment of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht 6229 HX, The Netherlands.
P Richard SchuurmanDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.
Maarten BotDepartment of Neurosurgery, Amsterdam University Medical Centers, Amsterdam 1105 AZ, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Connectivity-derived 7-Tesla MRI segmentation and intraoperative microelectrode recording can both assist subthalamic nucleus targeting for deep brain stimulation in Parkinson's disease. It remains unclear whether deep brain stimulation electrodes placed in the 7-Tesla MRI segmented subdivision with predominant projections to cortical motor areas (hyperdirect pathway) achieve superior motor improvement and whether microelectrode recording can accurately distinguish the motor subdivision. In 25 patients with Parkinson's disease, deep brain stimulation electrodes were evaluated for being inside or outside the predominantly motor-connected subthalamic nucleus (motor-connected subthalamic nucleus or non-motor-connected subthalamic nucleus, respectively) based on 7-Tesla MRI connectivity segmentation. Hemi-body motor improvement (Movement Disorder Society Unified Parkinson's Disease Rating Scale, Part III) and microelectrode recording characteristics of multi- and single-unit activities were compared between groups. Deep brain stimulation electrodes placed in the motor-connected subthalamic nucleus resulted in higher hemi-body motor improvement, compared with electrodes placed in the non-motor-connected subthalamic nucleus (80% versus 52%,

Indexed as

connectivitydeep brain stimulationParkinson’s diseasesubthalamic nucleustargeting

Identifiers

PMID38025271
PMCPMC10664414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.