Evidence map›Paper›PMID 38025240›Full record

ArticleKidney international reports2023

Loss-of-Function Homozygous Variant in

Hongyan Wu, Huan Xu, Song Lei, Zhi Yang, Shan Yang, Jingxue Du, Yi Zhou, Yunqiang Liu, Yuan Yang, Zhangxue Hu

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Total alkaloids fromFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hongyan WuDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Huan XuDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Song LeiDepartment of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Zhi YangDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Shan YangDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Jingxue DuDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Yi ZhouDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Yunqiang LiuDepartment of Medical Genetics, West China Hospital, Sichuan University, Chengdu, China.
Yuan YangDepartment of Medical Genetics, West China Hospital, Sichuan University, Chengdu, China.
Zhangxue HuDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China.
Sichuan University · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lipoprotein lipase (LPL) is an important enzyme in lipid metabolism, individuals with Methods: Renal biopsy was conducted to confirm the etiological factor of nephrotic syndrome in a 44-year-old Chinese man. Lipoprotein electrophoresis, Results: Renal biopsy revealed numerous CD68 positive foam cells infiltrated in the glomeruli; immunoglobulin and complement staining were negative; and electron microscopy revealed numerous lipid droplets and cholesterol clefts in the cytoplasm of foam cells. Lipoprotein electrophoresis revealed that the patient fulfilled the diagnostic criteria of type I hyperlipoproteinemia. The apoE genotype of the patient was the ε3/ε3 genotype. Whole-exome sequencing revealed an Conclusion:

Indexed as

cholesterol cleftsfoam cellhomozygous variantlipoprotein lipaserenal lipidosistype I hyperlipoproteinemia

Identifiers

PMID38025240
PMCPMC10658268
OpenAlexW4386171582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.