Evidence map›Paper›PMID 38025164›Full record

ArticleOphthalmology science2023

The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium.

Thomas V Johnson, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K Gokoffski, Jeffrey L Goldberg, William Guido, Alex L Kolodkin, Carol A Mason, Yvonne Ou and 4 more

Open access · goldAbstract read
In one paragraph

Article in Ophthalmology science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Generation of xenobiotic free retinofugal assembloids.Frontiers in cell and developmental biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 12 institutions in 3 countries.

Thomas V JohnsonWilmer Eye Institute and Cellular & Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Petr BaranovSchepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, Maryland.
Adriana Di PoloDepartment of Neuroscience, University of Montreal, Montreal, QC, Canada, Neuroscience Division, Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Brad FortuneDiscoveries in Sight Research Laboratories, Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, Oregon.
Kimberly K GokoffskiRoski Eye Institute, University of Southern California, Los Angeles, California.
Jeffrey L GoldbergSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
William GuidoDepartment of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky.
Alex L KolodkinSolomon H Snyder Department of Neuroscience and Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Carol A MasonZuckerman Mind Brain Behavior Institute, Department of Neuroscience, Department of Pathology & Cell Biology, and Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York.
Yvonne OuDepartment of Ophthalmology, University of California, San Francisco, California.
Thomas A RehDepartment of Biological Structure, University of Washington, Seattle, Washington.
Ahmara G RossScheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Brian C SamuelsDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama.
Donald J ZackDepartments of Ophthalmology (Wilmer Eye Institute), Neuroscience, Molecular Biology and Genetics, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USCentre Hospitalier de l’Université de Montréal · CAColumbia University · USLegacy Health · USMassachusetts Eye and Ear Infirmary · USPenn Presbyterian Medical Center · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Louisville · USUniversity of Southern California · USUniversity of Washington · USVision Eye Institute · AU

Funding

The Role of Zic Genes in Patterning the Binocular ProjectionR01EY015290 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MASON, CAROL A. · 2004 to 2023
$7.6M
Retinal Ganglion Cell Replacement in Clinically Relevant Models of Optic NeuropathyU24EY029893 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BARANOV, PETR, REX, TONIA S · 2018 to 2022
$7.2M
Overcoming Barriers to retinal ganglion cell replacement in experimental glaucomaU24EY033269 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI FORTUNE, BRAD, MEYER, JASON STEPHEN · 2021 to 2025
$7.0M
Supplement to EY021482 to carry out a screen for retinal regeneration using CRISPR-Cas9 gene activation.R01EY021482 · NEI · UNIVERSITY OF WASHINGTON · PI THOMAS A REH · 2011 to 2026
$6.3M
Retinal Ganglion Cell Dendrite and Synapse Regeneration in Glaucoma: the Role of Insulin Signaling.R01EY030838 · NEI · CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (UNIVERSITY OF MONTREAL HOSPITAL) · PI DI POLO, ADRIANA, FORTUNE, BRAD · 2020 to 2024
$2.9M
Advancing OCT evaluation to reveal early-stage changes in glaucomaR01EY030590 · NEI · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · PI FORTUNE, BRAD · 2019 to 2022
$2.2M
Neuronal plasticity in glaucomaR01EY028148 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OU, YVONNE · 2018 to 2022
$2.2M
Mitochondria: controllers of trauma-induced secondary neurodegeneration onsetR01EY036252 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TONIA S REX · 2024 to 2026
$1.4M
The Development of Gene Therapy Using SIRT1 Signaling to Treat Chronic GlaucomaK08EY030163 · NEI · UNIVERSITY OF PENNSYLVANIA · PI ROSS, AHMARA G. · 2019 to 2022
$958k
Transplantation of human stem cell-derived neurons for retinal ganglion cell replacement and optic nerve regeneration.K08EY031801 · NEI · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, THOMAS VINCENT · 2020 to 2024
$945k
In vivo Application of Electrical Fields Directs Retinal Ganglion Cell Axon RegenerationK08EY031797 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOKOFFSKI, KIMBERLY K · 2020 to 2023
$862k
Visualizing functional retinal integration of transplanted retinal ganglion cellsR21EY034332 · NEI · JOHNS HOPKINS UNIVERSITY · PI JOHNSON, THOMAS VINCENT · 2022 to 2023
$450k
NEI NIH HHS K08 EY030163NEI NIH HHS K08 EY031797NEI NIH HHS K08 EY031801NEI NIH HHS R01 EY015290NEI NIH HHS R01 EY021482NEI NIH HHS R01 EY028148NEI NIH HHS R01 EY030590NEI NIH HHS R01 EY030838NEI NIH HHS R01 EY036252NEI NIH HHS R13 EY034018NEI NIH HHS R21 EY034332NEI NIH HHS U24 EY029893NEI NIH HHS U24 EY033269
6 · The paper itself

Abstract

Purpose: The Retinal Ganglion Cell (RGC) Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) consortium was founded in 2021 to help address the numerous scientific and clinical obstacles that impede development of vision-restorative treatments for patients with optic neuropathies. The goals of the RReSTORe consortium are: (1) to define and prioritize the most critical challenges and questions related to RGC regeneration; (2) to brainstorm innovative tools and experimental approaches to meet these challenges; and (3) to foster opportunities for collaborative scientific research among diverse investigators. Design and Participants: The RReSTORe consortium currently includes > 220 members spanning all career stages worldwide and is directed by an organizing committee comprised of 15 leading scientists and physician-scientists of diverse backgrounds. Methods: Herein, we describe the structure and organization of the RReSTORe consortium, its activities to date, and the perceived impact that the consortium has had on the field based on a survey of participants. Results: In addition to helping propel the field of regenerative medicine as applied to optic neuropathies, the RReSTORe consortium serves as a framework for developing large collaborative groups aimed at tackling audacious goals that may be expanded beyond ophthalmology and vision science. Conclusions: The development of innovative interventions capable of restoring vision for patients suffering from optic neuropathy would be transformative for the ophthalmology field, and may set the stage for functional restoration in other central nervous system disorders. By coordinating large-scale, international collaborations among scientists with diverse and complementary expertise, we are confident that the RReSTORe consortium will help to accelerate the field toward clinical translation. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Collaborative scienceNeuroregenerationOptic neuropathyRegenerative medicineVision restoration

Identifiers

PMID38025164
PMCPMC10630665
OpenAlexW4386170029

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.