Evidence map›Paper›PMID 38024829›Full record

ArticleJournal of medicine and life2023

Diabetes mellitus, malnutrition, and sarcopenia: The bond is not explained by bioelectrical impedance analysis in older adults.

Francesco Salis, Francesca Zanda, Federica Cherchi, Benedetta Puxeddu, Luisa Sanna, Chiara Scudu, Silvia Serreli, Lorenzo Stanisci, Efisio Cossu, Antonella Mandas

Open access · diamondAbstract read
In one paragraph

Article in Journal of medicine and life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Francesco SalisDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Francesca ZandaDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Federica CherchiDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Benedetta PuxedduDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Luisa SannaDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Chiara ScuduDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Silvia SerreliDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, Sassari, Italy.
Lorenzo StanisciDepartment of Medicine, Surgery, and Pharmacy, University of Sassari, Sassari, Italy.
Efisio CossuUniversity Hospital Azienda Ospedaliero-Universitaria of Cagliari, Cagliari, Italy.
Antonella MandasDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
University of Cagliari · ITUniversity of Sassari · ITAzienda Ospedaliero-Universitaria Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As people age, their risk of diabetes mellitus (DM) and sarcopenia increases due to the decline in muscle mass and strength. Bioelectrical impedance analysis (BIA) is a method used to detect changes in body composition. The primary aim of the study was to determine the distribution of BIA variables among a group of non-DM people and two groups of patients with controlled and uncontrolled DM. The secondary aim was to establish the independent association between BIA-derived data, lipidic assets, and the prevalence of metabolic syndromes with DM. This study included a total of 235 participants who were categorized into three groups based on the presence of diabetes mellitus (DM) and their glycated hemoglobin (HbA1c) levels: non-DM, controlled DM (HbA1c≤7.0%), and uncontrolled DM (HbA1c>7.0%). Waist circumference (p=0.005), bone (p<0.001), muscular (p<0.001), and appendicular skeletal mass (p<0.001) were lower in the non-DM group, while sarcopenic risk (p<0.001), total cholesterol (p<0.001), and LDL (p<0.001), were higher. Grip strength (p<0.001), visceral fat (p=0.01), and phase angle (p=0.04) were significantly lower in non-DM than uncontrolled DM patients, as well as the number of drugs taken (p=0.014). A multivariate analysis highlighted that LDL (coefficient -0.006, p=0.01) was negatively associated, while bone mass (coefficient 0.498, p=0.0042) was positively associated with DM uncontrol. Our study shows that BIA may not be the ideal tool for distinguishing between elderly individuals with and without DM, as it can be affected by numerous covariates, including potential differences in glucometabolic and cardiovascular control.

Indexed as

Diabetes MellitusMalnutritionSarcopeniaAgedElectric ImpedanceGlycated HemoglobinHumansMuscle, SkeletalGlycated HemoglobinAC: Arm CircumferenceASM: Appendicular Skeletal Muscle MassBIA: Bioelectrical Impedance AnalysisBioelectrical Impedance Analysis (BIA)BMI: Body Mass IndexCC: Calf CircumferenceC.I.: Confidence IntervalDiabetes Mellitus (DM)DM: Diabetes MellitusECW: Extra-Cellular WaterelderlyHbA1c: glycated hemoglobinHDL: High-Density LipoproteinsLDL: Low-Density LipoproteinsmalnutritionMM: Total Muscle MassMNA: Mini Nutritional AssessmentsarcopeniaSD: Standard DeviationTBW: Total Body WaterWC: Waist Circumference

Identifiers

PMID38024829
PMCPMC10652670
OpenAlexW4389180702

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.