Evidence map›Paper›PMID 38024702›Full record

ArticleACS omega2023

Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice.

Akika Nagata, Shiori Oishi, Nanako Kirishita, Keita Onoda, Takuma Kobayashi, Yuko Terada, Akira Minami, Nanami Senoo, Yasukiyo Yoshioka, Kunitoshi Uchida and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Akika NagataGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Shiori OishiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Nanako KirishitaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Keita OnodaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Takuma KobayashiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Yuko TeradaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Akira MinamiDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Nanami SenooGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Yasukiyo YoshiokaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Kunitoshi UchidaGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Keisuke ItoGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Shinji MiuraGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.
Noriyuki MiyoshiGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 4228526, Japan.ORCID https://orcid.org/0000-0002-4233-4282
University of Shizuoka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-temperature-induced fatty acid desaturation is highly conserved in animals, plants, and bacteria. Allyl isothiocyanate (AITC) is an agonist of the transient receptor potential ankyrin 1 (TRPA1), which is activated by various chemophysiological stimuli, including low temperature. However, whether AITC induces fatty acid desaturation remains unknown. We showed here that AITC increased levels of glycerophospholipids (GP) esterified with unsaturated fatty acids, especially docosahexaenoic acid (DHA) in TRPA1-expressing HEK cells. Additionally, GP-DHA including phosphatidylcholine (18:0/22:6) and phosphatidylethanolamine (18:0/22:6) was increased in the brain and liver of AITC-administered mice. Moreover, intragastrical injection of AITC in ovariectomized (OVX) female C57BL/6J mice dose-dependently shortened the Δlatency time determined by the Morris water maze test, indicating AITC ameliorated the cognitive function decline in these mice. Thus, the oral administration of AITC maintains GP-DHA in the liver and brain, proving to be a potential strategy for preventing cognitive decline.

Identifiers

PMID38024702
PMCPMC10652735
OpenAlexW4388125752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.