Evidence map›Paper›PMID 38024683›Full record

ArticleACS omega2023

Targeting the Expanded

Jiaxin Hu, Xiulong Shen, Mahboubeh Kheirabadi, Matthew D Streeter, Ziqing Qian, V Vinod Mootha, David R Corey

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jiaxin HuDepartment of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, United States.
Xiulong ShenEntrada Therapeutics Inc., Boston, Massachusetts 02210, United States.
Mahboubeh KheirabadiEntrada Therapeutics Inc., Boston, Massachusetts 02210, United States.
Matthew D StreeterEntrada Therapeutics Inc., Boston, Massachusetts 02210, United States.
Ziqing QianEntrada Therapeutics Inc., Boston, Massachusetts 02210, United States.
V Vinod MoothaDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas 75390, United States.
David R CoreyDepartment of Pharmacology and Biochemistry, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390, United States.ORCID https://orcid.org/0000-0001-8973-493X
Southwestern Medical Center · US

Funding

Stem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9M
Recognition of Cellular Targets by single and double-stranded nucleic acidsR35GM118103 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI David R Corey · 2016 to 2026
$5.7M
Laying a Foundation for Precision Medicine for Fuchs' DystrophyR01EY022161 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI MOOTHA, VENKATESWARA VINOD · 2012 to 2024
$4.8M
NEI NIH HHS P30 EY030413NEI NIH HHS R01 EY022161NIGMS NIH HHS R35 GM118103
6 · The paper itself

Abstract

Fuchs' corneal endothelial dystrophy (FECD) is a major cause of vision loss. Corneal transplantation is the only effective curative treatment, but this surgery has limitations. A pharmacological intervention would complement surgery and be beneficial for many patients. FECD is caused by an expanded CUG repeat within intron 2 of the

Identifiers

PMID38024683
PMCPMC10652360
OpenAlexW4388212334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.