Evidence map›Paper›PMID 38024616›Full record

ArticleEJHaem2023

Real-world experience of novel multiple myeloma treatments in a large, single-center cohort in Finland.

Heidi Loponen, Juha Mehtälä, Tero Ylisaukko-Oja, Oscar Brück, Kimmo Porkka, Perttu Koskenvesa, Kirsi Saukkonen, Juha Lievonen

Abstract read
In one paragraph

Article in EJHaem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heidi LoponenMedEngine Oy Helsinki Finland.ORCID https://orcid.org/0009-0005-8603-0415
Juha MehtäläMedEngine Oy Helsinki Finland.
Tero Ylisaukko-OjaMedEngine Oy Helsinki Finland.
Oscar BrückHelsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki Helsinki Finland.
Kimmo PorkkaHelsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki Helsinki Finland.
Perttu KoskenvesaHelsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki Helsinki Finland.
Kirsi SaukkonenAmgen Ab Espoo Finland.
Juha LievonenHelsinki University Hospital Comprehensive Cancer Center, Department of Hematology University of Helsinki Helsinki Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this single-center study, we aimed to describe the characteristics, treatment patterns, and outcomes of patients with multiple myeloma (MM) following treatment with bortezomib, carfilzomib, daratumumab, ixazomib, lenalidomide or pomalidomide-based regimens. Data were collected retrospectively from a study cohort of patients receiving a MM treatment in the Hospital District of Helsinki and Uusimaa (HUS) in Finland between 2016-2020. In total, 472 patients were included in the study. Median age was 68.2 years and nearly 25% had a high cytogenetic risk according to the International Myeloma Working Group categorization. In 2018-2020, the spectrum of regimens used as third- or later-line therapy was notably broader than in 2016-2017. The overall response rates for patients who received the most novel regimens (available ≤ 5 years) in second or third line of therapy (

Indexed as

carfilzomibmultiple myelomanovel treatmentstreatment‐related outcomes

Identifiers

PMID38024616
PMCPMC10660399

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.