Evidence map›Paper›PMID 38024589›Full record

ArticleEJHaem2023

Daratumumab-based induction and autologous transplantation in concomitant multiple myeloma and chronic myeloid leukemia.

Carmine Liberatore, Francesca Fioritoni, Annalisa Natale, Guido Montanaro, Gaetano La Barba, Cecilia Passeri, Ornella Iuliani, Bianca Fabi, Stefano Baldoni, Donatella Fantasia and 5 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in EJHaem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Carmine LiberatoreHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Francesca FioritoniHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Annalisa NataleBone Marrow Transplant Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Guido MontanaroHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Gaetano La BarbaHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Cecilia PasseriBlood Bank Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Ornella IulianiBlood Bank Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Bianca FabiBlood Bank Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Stefano BaldoniBlood Bank Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Donatella FantasiaOnco-hematological Genetics, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Giuseppe CalabreseOnco-hematological Genetics, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Patrizia AccorsiBone Marrow Transplant Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Stella SantaroneHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Stefano PuliniHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Mauro Di IanniHematology Unit, Department of Oncology and Hematology Pescara Hospital Pescara Italy.
Azienda USL di Pescara · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coexistence of chronic myeloid leukemia (CML) and multiple myeloma (MM) is a rare clinical condition. By means of FISH and molecular analysis on both sorted CD138 plasma cells and cryopreserved CD34 stem cells, a distinct clonal origin of the hematological malignancies was demonstrated in our case. We report on the first patient diagnosed with CML and MM treated with daratumumab, bortezomib, thalidomide, and dexamethasone (Dara-VTd) induction, stem-cell collection, and autologous stem cell transplantation (ASCT). The co-administration of Dara-VTd and imatinib proved feasible and highly effective in the management of both CML and MM. Despite concerns with stem cell mobilization and collection in patients exposed to daratumumab, in our experience the use of higher cyclophosphamide dose 4 g/m

Indexed as

CMLmultiple myelomamyelomatransplantation

Identifiers

PMID38024589
PMCPMC10660090
OpenAlexW4386640338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.