Evidence map›Paper›PMID 38024429›Full record

ArticleAsian journal of urology2023

Unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection in Stage II non-seminomatous germ cell tumor: A tertiary care experience.

Dario Franzese, Antonio Tufano, Alessandro Izzo, Raffaele Muscariello, Giovanni Grimaldi, Giuseppe Quarto, Luigi Castaldo, Sabrina Rossetti, Savio Domenico Pandolfo, Sonia Desicato and 4 more

Abstract read
In one paragraph

Article in Asian journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Exploring the microbiome-gut-testis axis in testicular germ cell tumors.Frontiers in cellular and infection microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dario FranzeseDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Antonio TufanoUrology Unit, Department of Maternal-Child and Urological Sciences, "Sapienza" University, Rome, Italy.
Alessandro IzzoDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Raffaele MuscarielloDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Giovanni GrimaldiDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Giuseppe QuartoDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Luigi CastaldoDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Sabrina RossettiDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Savio Domenico PandolfoDepartment of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy.
Sonia DesicatoDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.
Paola Del PreteScientific Directorate, Istituto Nazionale Tumori di Napoli, IRCCS "G. Pascale", Naples, Italy.
Matteo FerroDivision of Urology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.
Sandro PignataDivision of Medical Oncology, Department of Uro-Gynaecological Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale", IRCCS, Naples, Italy.
Sisto PerdonàDepartment of Urology, National Cancer Institute, Pascale Foundation, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) represents an integral component of the management of patients with non-seminomatous germ cell tumor (NSGCT). Modified templates have been proposed to minimize the surgical morbidity of the procedure. Moreover, the implementation of robotic surgery in this setting has been explored. We report our experience with unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection (PC-rRPLND) for clinical Stages IIA and IIB NSGCTs. Methods: A retrospective single institution review was performed including 33 patients undergoing PC-rRPLND for Stages IIA and IIB NSGCTs between January 2015 and February 2019. Following orchiectomy, patients were scheduled for chemotherapy with three cycles of bleomycin-etoposide-cisplatin. Patients with a residual tumor of <5 cm and an ipsilateral metastatic disease on pre- and post-chemotherapy CT scans were eligible for a unilateral template in absence of rising tumor markers. Descriptive statistics were provided for demographics, clinical characteristics, intraoperative and postoperative parameters. Perioperative, oncological, and functional outcomes were recorded. Results: Overall, 7 (21.2%) patients exhibited necrosis or fibrosis; 14 (42.4%) had mature teratoma; and 12 (36.4%) had viable tumor at final histology. The median lymph node size at surgery was 25 (interquartile range [IQR] 21-36) mm. Median operative time was 180 (IQR 165-215) min and no major postoperative complications were observed. Anterograde ejaculation was preserved in 75.8% of patients. Median follow-up was 26 (IQR 19-30) months and a total of three recurrences were recorded. Conclusion: PC-rRPLND is a reliable and technically reproducible procedure with safe oncological outcomes and acceptable postoperative ejaculatory function in well selected patients with NSGCTs.

Indexed as

Modified templateNon-seminomatous germ cell tumorPost-chemotherapyRetroperitoneal lymph node dissectionRobot-assisted retroperitoneal lymph node dissectionTestis tumorUnilateral dissection

Identifiers

PMID38024429
PMCPMC10659970

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.