Evidence map›Paper›PMID 38024308›Full record

ArticleNanoscale advances2023

Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles.

Brydie A Thomas-Moore, Simone Dedola, David A Russell, Robert A Field, María J Marín

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Advancements and emerging trends in photodynamic therapy: innovations in cancer treatment and beyond.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Review
  3. Article
  4. Advanced pharmaceutical bulletin · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brydie A Thomas-MooreIceni Glycoscience Ltd. Norwich Research Park Norwich NR4 7TJ UK m.marin-altaba@uea.ac.uk.ORCID https://orcid.org/0000-0001-5386-9568
Simone DedolaIceni Glycoscience Ltd. Norwich Research Park Norwich NR4 7TJ UK m.marin-altaba@uea.ac.uk.
David A RussellSchool of Chemistry, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK.ORCID https://orcid.org/0000-0001-9915-4699
Robert A FieldIceni Glycoscience Ltd. Norwich Research Park Norwich NR4 7TJ UK m.marin-altaba@uea.ac.uk.ORCID https://orcid.org/0000-0001-8574-0275
María J MarínSchool of Chemistry, University of East Anglia Norwich Research Park Norwich NR4 7TJ UK.ORCID https://orcid.org/0000-0001-8021-5498
University of East Anglia · GBNorwich Research Park · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Photodynamic therapy (PDT) uses a non-toxic light sensitive molecule, a photosensitiser, that releases cytotoxic reactive oxygen species upon activation with light of a specific wavelength. Here, glycan-modified 16 nm gold nanoparticles (glycoAuNPs) were explored for their use in targeted PDT, where the photosensitiser was localised to the target cell through selective glycan-lectin interactions. Polyacrylamide (PAA)-glycans were chosen to assess glycan binding to the cell lines. These PAA-glycans indicated the selective uptake of a galactose-derivative PAA by two breast cancer cell lines, SK-BR-3 and MDA-MD-231. Subsequently, AuNPs were modified with a galactose-derivative ligand and an amine derivate of the photosensitiser chlorin e6 was incorporated to the nanoparticle surface

Identifiers

PMID38024308
PMCPMC10662151
OpenAlexW4388188650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.