Evidence map›Paper›PMID 38023429›Full record

ArticleVeterinary medicine international2023

Analytical Validation of MINI-PET as Point-of-Care for Erythrocyte Sedimentation Rate Measure in Horses.

Carolina Pieroni, Andrea Grassi, Marianna Pantoli, Mirko Berretti, Stefano Messina, Chiara Giovannini, George Lubas, Daniela Diamanti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carolina PieroniDIESSE- Diagnostica Senese S.p.A. Società Benefit, Strada dei Laghi, 35-39, Monteriggioni, Siena, Italy.ORCID https://orcid.org/0000-0003-2997-2922
Andrea GrassiI-Vet Diagnostica Veterinaria, Via Ettore Majorana, 10, Flero, Brescia, Italy.ORCID https://orcid.org/0000-0002-9465-2418
Marianna PantoliI-Vet Diagnostica Veterinaria, Via Ettore Majorana, 10, Flero, Brescia, Italy.ORCID https://orcid.org/0009-0000-9737-2238
Mirko BerrettiDIESSE- Diagnostica Senese S.p.A. Società Benefit, Strada dei Laghi, 35-39, Monteriggioni, Siena, Italy.ORCID https://orcid.org/0000-0003-4122-8282
Stefano MessinaAzienda Ospedaliera Universitaria Senese, V.le Mario Bracci, 11, Siena, Italy.ORCID https://orcid.org/0009-0009-4538-7476
Chiara GiovanniniIl Ceppo Equine Hospital, Strada Monteresi 3, Monteriggioni, Siena, Italy.ORCID https://orcid.org/0009-0007-8286-0846
George LubasClinica Veterinaria Colombo, VetPartners Italia, V.le Colombo 153, Lido di Camaiore, Lucca, Italy.ORCID https://orcid.org/0000-0002-9430-1060
Daniela DiamantiDIESSE- Diagnostica Senese S.p.A. Società Benefit, Strada dei Laghi, 35-39, Monteriggioni, Siena, Italy.ORCID https://orcid.org/0000-0002-1078-1889
DIESSE Diagnostica Senese S.p.A. Società Benefit (Italy) · ITAzienda Ospedaliera Universitaria Senese · ITIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The erythrocyte sedimentation rate (ESR) is a widely used diagnostic assay in human medicine but nowadays poorly applied in veterinary medicine. This test measures the speed (millimeters per hour) at which red blood cells settle in a whole anticoagulated blood tube. In human medicine, high ESR values are associated with various disorders, including infections, rheumatoid arthritis, oncologic diseases, and other inflammatory conditions. The ESR can also be influenced by some factors such as age and gender. In veterinary medicine, the ESR with the Westergren manual method was almost forgotten over the years due to blood consumption and long turn-around time. The instrument MINI-PET, using a modified Westergren method, does not require blood consumption or release waste product and recently has been applied in canine medicine. The aims of the study in the horse were as follows: to establish the appropriate time to read the ESR with the Westergren reference method; to compare the MINI-PET ESR results with the reference technique; to assess the ESR reference intervals with MINI-PET; and to establish the ESR stability from collection at different time points by MINI-PET. Using 150 horses, we established 60 minutes as the appropriate time for ESR reading with the Westergren method. Moreover, ESR results obtained in 8 minutes with MINI-PET showed a good correlation with the Westergren ESR. Reference intervals (RIs) with MINI-PET were established in mm/h for the healthy horses (geldings 18.6-100.1; stallions, 13.8-55.7; and mares 1-73.7) according to the American Society of Veterinary Clinical Pathology guidelines. In addition, the ESR stability from the blood collection time was evaluated in the MINI-PET on 15 horses: at room temperature, ESR is stable up to 8 hours and at 4°C up to 24 hours. In conclusion, MINI-PET represents a rapid and reliable tool for measuring ESR in horses, offering a valid option to replace the traditional manual technique.

Identifiers

PMID38023429
PMCPMC10665103
OpenAlexW4388687299

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.