Evidence map›Paper›PMID 38023414›Full record

ArticleAmerican journal of blood research2023

A randomized controlled trial to explore the safety and efficacy of irradiated buffy-coat granulocytes in pediatric patients with febrile neutropenia.

Mohanaraj Ramachandran, Aditya Kumar Gupta, Jagdish Prasad Meena, Ashish Datt Upadhyay, Poonam Coshic, Rakesh Lodha, Rachna Seth

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of blood research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mohanaraj RamachandranDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India.
Aditya Kumar GuptaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India.
Jagdish Prasad MeenaDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India.
Ashish Datt UpadhyayDepartment of Biostatistics, All India Institute of Medical Sciences New Delhi, India.
Poonam CoshicDepartment of Transfusion Medicine, All India Institute of Medical Sciences New Delhi, India.
Rakesh LodhaDivision of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India.
Rachna SethDivision of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransfusion of granulocytes obtained by apheresis is beneficial in febrile neutropenia (FN) but expensive and time-consuming. Buffy-coat-derived granulocytes could be an alternative. We studied the efficacy and safety of the administration of irradiated buffy-coat-derived granulocytes along with the standard of care in pediatric high-risk (HR) FN.

methodsSixty children ≤18 years with malignancy and chemotherapy-induced HR FN were randomized to either the granulocyte transfusion (GT) arm which received irradiated buffy-coat derived granulocyte transfusion along with the standard treatment or the standard treatment (ST) arm.

resultsBaseline characteristics, day-to-defervescence, antibiotic duration, hospital stay, and mortality were comparable between the groups. A significant difference was seen in days to achieve absolute neutrophil count (ANC) >500/mm

conclusionBuffy-coat-derived granulocyte transfusion was safe and led to early hematological recovery but was not associated with survival benefits. Future studies with earlier initiation in the intended dose could be undertaken to generate more evidence.

Indexed as

buffy-coat granulocytesFebrile neutropeniapediatrics

Identifiers

PMID38023414
PMCPMC10658032
OpenAlexW4389180477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.