Evidence map›Paper›PMID 38022577›Full record

ArticleFrontiers in immunology2023

A human 3D immune competent full-thickness skin model mimicking dermal dendritic cell activation.

Johanna Maria Hölken, Katja Friedrich, Marion Merkel, Nelli Blasius, Ursula Engels, Timo Buhl, Karsten Rüdiger Mewes, Lars Vierkotten, Nicole Elisabeth Teusch

Open access · goldAbstract readComment
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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  16. An organotypic human melanoma-in-skin model as anImmuno-oncology technology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Johanna Maria HölkenInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Katja FriedrichInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Marion MerkelAlternative Methods and Tissue Engineering, Henkel AG & Co. KGaA, Düsseldorf, Germany.
Nelli BlasiusAlternative Methods and Tissue Engineering, Henkel AG & Co. KGaA, Düsseldorf, Germany.
Ursula EngelsAlternative Methods and Tissue Engineering, Henkel AG & Co. KGaA, Düsseldorf, Germany.
Timo BuhlDepartment of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.
Karsten Rüdiger MewesAlternative Methods and Tissue Engineering, Henkel AG & Co. KGaA, Düsseldorf, Germany.
Lars VierkottenAlternative Methods and Tissue Engineering, Henkel AG & Co. KGaA, Düsseldorf, Germany.
Nicole Elisabeth TeuschInstitute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Henkel (Germany) · DEHeinrich Heine University Düsseldorf · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have integrated dermal dendritic cell surrogates originally generated from the cell line THP-1 as central mediators of the immune reaction in a human full-thickness skin model. Accordingly, sensitizer treatment of THP-1-derived CD14

Indexed as

DinitrochlorobenzeneInterleukin-8CytokinesDendritic CellsHumansInterleukin-6Langerhans CellsCytokinesDinitrochlorobenzeneInterleukin-6Interleukin-8CD86dermal dendritic cellDNCBfull-thickness skin modelNF-κBnickelp38 MAPK

Identifiers

PMID38022577
PMCPMC10657825
OpenAlexW4388422824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.