Evidence map›Paper›PMID 38022568›Full record

ArticleFrontiers in immunology2023

The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study.

Jelena Drulovic, Tatjana Pekmezovic, Olivera Tamas, Ivan Adamec, Dejan Aleksic, Marko Andabaka, Vanja Basic Kes, Silva Butkovic Soldo, Mirjana Cukic, Livija Despinic and 20 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 14 institutions in 5 countries.

Jelena DrulovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Tatjana PekmezovicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Olivera TamasClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Ivan AdamecDepartment of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.
Dejan AleksicDepartment of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Marko AndabakaClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Vanja Basic KesDepartment of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Silva Butkovic SoldoDepartment of Neurology, Osijek University Hospital Centre, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia.
Mirjana CukicDepartment of Neurology, Clinical Center of Montenegro, Podgorica, Montenegro.
Livija DespinicDepartment of Neurology, General Hospital Subotica, Subotica, Serbia.
Evica DincicDepartment of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia.
Jasminka Djelilovic VranicClinic of Neurology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Sanja GrgicClinic of Neurology, University Clinical Center of the Republika Srpska, Banja Luka, Bosnia and Herzegovina.
Mario HabekDepartment of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.
Sonya Ivanova HristovaDepartment of Neurology, University Neurological Hospital St Naum, Medical University Sofia, Sofia, Bulgaria.
Jovana IvanovicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Aleksa JovanovicInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Vanja JovicevicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Magdalena Krbot SkoricDepartment of Neurology, University Hospital Center of Zagreb, Zagreb, Croatia.
Igor KuzmanovskiUniversity Clinic of Neurology, Clinical Center ''Mother Teresa'', Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, North Macedonia.
Gorica MaricInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Sarlota MesarosClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Ivan Gospodinov MilanovDepartment of Neurology, University Neurological Hospital St Naum, Medical University Sofia, Sofia, Bulgaria.
Svetlana Miletic DrakulicDepartment of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Osman SinanovicDepartment of Neurology, University Clinical Center Tuzla, Medical Faculty University of Tuzla, Tuzla, Bosnia and Herzegovina.
Ingrid Skarpa PrpicClinic of Neurology, Clinical Hospital Center Rijeka, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
Josip SremecClinic of Neurology, Clinical Hospital ''Sveti Duh'', Zagreb, Croatia.
Daliborka TadicClinic of Neurology, University Clinical Center of the Republika Srpska, Banja Luka, Bosnia and Herzegovina.
Gordana ToncevDepartment of Neurology, Kragujevac Clinical Center, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Dragoslav SokicClinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Centar za Promociju Nauke · RSUniversity of Belgrade · RSUniversity of Kragujevac · RSUniversity clinical center of Republika Srpska · BAUniversity Hospital Centre Zagreb · HRUniversity of Zagreb · HRKlinička bolnica "Sveti Duh" · HRMilitary Medical Academy · RSSaints Cyril and Methodius University of Skopje · MKUniversity of Montenegro · MEUniversity of Osijek · HRUniversity of Rijeka · HRUniversity of Sarajevo · BAUniversity of Tuzla · BA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The health-related quality of life (HRQoL) of people with (Pw) multiple sclerosis (MS) is usually deteriorated. It has been recently suggested that comorbidities may have the negative influence on the quality of life of the PwMS, but according to the best of our knowledge, only one study investigated, although in a very small cohort, the impact of individual comorbidity on the quality of life of PwMS. The aim of our investigation was to assess, in an international, multicentric study, the impact of comorbid seizure/epilepsy on the HRQoL in PwMS. Methods: We conducted cross-sectional study at numerous neurological centers in Serbia, Croatia, Bulgaria, Montenegro, Northern Macedonia, and Bosnia and Herzegovina (Federation of Bosnia and Herzegovina and Republic of Srpska). For each patient, demographic and clinical data were collected, including Expanded disability status scale (EDSS) score. Beck Depression Inventory (BDI) and the 36-Item Short Form Health Survey (SF-36) questionnaires were administered to all patients. Results: The study comprised 326 PwMS in total, 127 PwMS with seizure/epilepsy and 209 PwMS without. Both mean Physical health composite (PHC) and mental health composite (MHC) scores, were statistically significantly higher in PwMS without seizure/epilepsy, implicating worse quality of life in PwMS with comorbid seizure/epilepsy. Presence of seizure/epilepsy in pwMS was statistically significant independent predictor of both PHC and MHC, in multivariate linear regression model after adjustment for potential confounding variables. The hierarchical multivariate regression analysis was performed in order to establish the most important predictors of the PHC and MHC of the SF-36, in PwMS with seizure/epilepsy; older age, higher level of disability, as measured by EDSS, higher depression score, drug-resistant epilepsy and shorter time since last seizure were found to significantly predict worse MHC score in PwMS with seizure/epilepsy. Discussion: Our results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy.

Indexed as

EpilepsyMultiple SclerosisComorbidityCross-Sectional StudiesHumansQuality of LifeSeizurescomorbiditydepressionepilepsymultiple sclerosisquality of lifeseizure

Identifiers

PMID38022568
PMCPMC10662040
OpenAlexW4388460776

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.