Evidence map›Paper›PMID 38022565›Full record

ArticleFrontiers in immunology2023

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells.

Sougata Roy, Sudeep Roy, Bidesh Mahata, Jhuma Pramanik, Marco L Hennrich, Anne-Claude Gavin, Sarah A Teichmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 5 countries.

Sougata RoyDepartment of Biology, Ashoka University, Rajiv Gandhi Education City, Sonipat, Haryana, India.
Sudeep RoyDepartment of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czechia.
Bidesh MahataDivision of Immunology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Jhuma PramanikDivision of Immunology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
Marco L HennrichStructural and Computational Biology Unit, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany.
Anne-Claude GavinDepartment for Cell Physiology and Metabolism, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland.
Sarah A TeichmannCellular Genetics, Wellcome Sanger Institute, Cambridge, United Kingdom.
University of Cambridge · GBAshoka University · INUniversity of Geneva · CHWellcome Sanger Institute · GB

Funding

Medical Research Council BB/V006126/1Medical Research Council MR/V028995/1
6 · The paper itself

Abstract

Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5

Indexed as

PregnenoloneTh2 CellsCarrier ProteinsMolecular Dynamics SimulationSteroidsCarrier ProteinsPregnenoloneSteroidschemoproteomicsclick chemistrylymphosteroidpregnenoloneTH2

Identifiers

PMID38022565
PMCPMC10644475
OpenAlexW4388047184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.