ReviewFrontiers in immunology2023
Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.
Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hypocrellin-Mediated PDT: A Systematic Review of Its Efficacy, Applications, and Outcomes.International journal of molecular sciences · 2025Pooled it
- A Critical Synthesis of Natural Photosensitizers in Photodynamic Food Preservation Covering Mechanisms, Matrix-Specific Applications, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Natural Product-Based Upconversion-Downshifting Photosensitizers in Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Hydroxy-Group Topology as a Molecular Trigger Between Antioxidant and Photosensitizing Properties in Dihydroxynaphthalenes.ACS omega · 2026Article
- Liver-Targeted Gallium-Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Piceatannol from Passion Fruit Seed Waste: A Circular Bioeconomy-Driven Pathway Toward a Skin-Targeted Bioactive.International journal of molecular sciences · 2026Review
- Photostability and antimicrobial performance of natural yellow pigments in food systems: Insights into light-induced degradation and functional consequences.Food chemistry: X · 2026Review
- Hypericin as a Photodynamic Immunomodulator: A Natural Compound for Dermatological Therapy.Drug design, development and therapy · 2026Review
- Resveratrol as an immune checkpoint inhibitor to enhance the efficacy of breast cancer immunotherapy.Iranian journal of basic medical sciences · 2026Review
- The Impact of Antimicrobial Photodynamic Therapy (aPDT) with Various Photosensitizers on the Bond Strength of Orthodontic Brackets.Journal of lasers in medical sciences · 2026Article
- Hyperoside promotes osteoblast differentiation by increasing osteoclast-derived migrasomes to alleviate osteoporosis.American journal of translational research · 2026Article
- Beyond traditional therapies: a narrative overview of antimicrobial photodynamic therapy in combating bacterial and viral infections.Archives of microbiology · 2025Review
- In Vitro Antifungal Efficacy of Blue-Light Photodynamic Therapy with Curcumin and Riboflavin Formulation Activated by 450 nm Diode Laser AgainstPharmaceutics · 2025Article
- Comparison of the effects of continuous and pulsed blue light for reduction of Enterococcus faecalis biofilms.Lasers in medical science · 2025Article
- Redox Homeostasis as a Key Regulator of Intramolecular Cyclization in Fungal Perylenequinones.ACS chemical biology · 2025Article
- Natural Biomolecules and Light: Antimicrobial Photodynamic Strategies in the Fight Against Antibiotic Resistance.International journal of molecular sciences · 2025Review
- The Role of Photodynamic Therapy Mediated by Natural Photosensitisers in the Management of Peri-Implantitis: A Systematic Review.Pharmaceutics · 2025Review
- Anti-virulence effect of photoactivated nano-quercetin by diode laser on Aggregatibacter actinomycetemcomitans.AMB Express · 2025Article
- Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest developments and future implications of using natural polyphenols as PSs in aPDT. Paramount polyphenolic compounds, including curcumin, hypericin, quercetin, hypocrellin, celastrol, riboflavin, resveratrol, gallic acid, and aloe emodin, are elaborated upon with respect to their structural characteristics, absorption properties, and antimicrobial effects. Furthermore, the aPDT mechanism, specifically its targeted action on microbial cells and biofilms, is also discussed. Polyphenolic natural products demonstrate immense potential as PSs in aPDT, representing a promising alternate approach to counteract antibiotic-resistant bacteria and biofilm-related infections.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.