Evidence map›Paper›PMID 38022509›Full record

ArticleFrontiers in immunology2023

The promiscuous development of an unconventional Qa1b-restricted T cell population.

Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A Robey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Preselection CD4bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Michael Manoharan Valerio *Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Kathya Arana *Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Jian GuanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Shiao Wei ChanDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Xiaokun YangDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Nadia KurdDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Angus LeeGene Targeting Facility Cancer Research Laboratory, University of California Berkeley, Berkeley, CA, United States.
Nilabh ShastriDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Laurent CoscoyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
Ellen A RobeyDivision of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, United States.
University of California, Berkeley · USJohns Hopkins University · USTarget (United States) · US

Funding

Training Research Educators in Minnesota (TREM) whilst increasing diversityK12GM119955 · NIGMS · UNIVERSITY OF MINNESOTA · PI David Irwin Greenstein, Julia Willett · 2017 to 2026
$6.5M
Immunology & Pathogenesis Program Training GrantT32AI100829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton, ELLEN A ROBEY · 2012 to 2026
$4.7M
Presentation of Qa-1 restricted peptides during homeostasis and viral infectionR01AI149341 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI COSCOY, LAURENT, ROBEY, ELLEN A · 2020 to 2024
$2.9M
NIAID NIH HHS R01 AI149341NIAID NIH HHS T32 AI100829NIGMS NIH HHS K12 GM119955
6 · The paper itself

Abstract

MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1

Indexed as

CD8-Positive T-LymphocytesReceptors, Antigen, T-Cell, alpha-betaAnimalsGenes, MHC Class IIMicePeptidesThymocytesPeptidesReceptors, Antigen, T-Cell, alpha-betaIELMHC-Enon-classical MHC-1T cell developmentunconventional T cells

Identifiers

PMID38022509
PMCPMC10644506
OpenAlexW4388068715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.