Evidence map›Paper›PMID 38022445›Full record

ReviewAnnals of Indian Academy of Neurology

The Impact of Elevated Troponin Levels on Clinical Outcomes in Patients with Acute Ischemic Stroke: A Systematic Review.

Aakanksha Pitliya, Esraa M AlEdani, Japneet K Bhangu, Khalid Javed, Prabhleen K Manshahia, Shamsun Nahar, Srishti Kanda, Uzair Chatha, Victor Odoma, Lubna Mohammed

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Aakanksha PitliyaDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Esraa M AlEdaniDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Japneet K BhanguDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Khalid JavedDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Prabhleen K ManshahiaDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Shamsun NaharDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Srishti KandaDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Uzair ChathaDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Victor OdomaDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
Lubna MohammedDepartment of Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, CA, USA.
California Institute of Behavioral Neurosciences and Psychology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association between high cardiac troponin (cTn) levels and stroke characteristics and outcomes remains unclear. This systematic review aimed to determine the prevalence and clinical implications of elevated cTn levels in patients with acute ischemic stroke (AIS). We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines. A comprehensive search of PubMed, Google Scholar, Science Direct, and Research Gate databases was conducted to identify relevant studies published in English up to May 2023. This study included all reports on serum cTn levels and AIS. Two independent reviewers assessed study quality and bias using study-specific tools before inclusion. The systematic review included a total of 14 articles with 16906 participants, including one systematic review, one randomized controlled trial (RCT), and 12 observational studies. The results of this systematic review indicate that the prevalence of high cTn levels is averaged at 17.9%, or 1 in 5 individuals, who have an AIS. The review emphasizes the detrimental effects of increased cTn levels on outcomes for in-hospital and all-cause mortality as well as cardiovascular outcomes in patients with AIS. These results demonstrate that serum cTn has the potential to be a useful tool for risk classification and prognostic assessment in individuals with AIS. AIS patients with elevated serum cTn at baseline have an increased risk of mortality. Early and routine evaluation of serum cTn may contribute to the timely detection of co-morbid cardiovascular injury and prevent unfavorable outcomes in patients with AIS.

Indexed as

Acute ischemic strokebrain ischemiacardiac cTncerebrovascular accidentcTnstroke

Identifiers

PMID38022445
PMCPMC10666897
OpenAlexW4387943451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.