ReviewThe Japanese dental science review2023
The relationships between mastication and cognitive function: A systematic review and meta-analysis.
Review in The Japanese dental science review, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Factors associated with oral frailty in older adults: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- The Longitudinal Associations of Denture Use and Subjective Chewing Difficulty with Depressive Symptoms Among Middle-Aged and Older Adults: A Sex-Stratified Analysis of the Korean Longitudinal Study of Aging (2006-2022).Healthcare (Basel, Switzerland) · 2026Article
- Oral Structural and Functional Impairment in Relation to Depressive Outcomes in Older Adults: A Systematic Review and Meta-Analysis of Observational Studies.Diseases (Basel, Switzerland) · 2026Review
- Exploring the Relationship Between Cerebral Blood Flow and Oral Exercise Using Head-Mounted Near-Infrared Spectroscopy.Dysphagia · 2026Article
- Low Skeletal Muscle Mass as a Key Predictor of Postoperative Diet Outcomes in Circumferential Hypopharyngeal Cancer Reconstruction.Laryngoscope investigative otolaryngology · 2026Article
- Association of oral frailty and its dimensions with cognitive impairment among older adults in China: a cross-sectional study.BMC oral health · 2026Observational
- Investigating the dynamic association of multiple risk factors on cognitive impairment in older people: a retrospective cohort study in Baisha Town, Hepu County, China.BMC geriatrics · 2026Article
- Association between reduced chewing-induced brain blood flow and cognitive performance in mandibular prognathism patients in a pilot study.Scientific reports · 2026Article
- Article
- Long-term dental care utilization trajectories as behavioral markers of cognitive aging: a 14-year national cohort study.Frontiers in public health · 2026Article
- Oral frailty and activities of daily living among community-dwelling older adults: the indirect association of nutritional status.Frontiers in public health · 2026Observational
- Physical and Psychosocial Frailty Indicators as Predictors of Oral Frailty in Community-Dwelling Older Women.Journal of oral rehabilitation · 2025Article
- Relationship Between Oral Motor and Cognitive Function in Community-Dwelling Korean Older Adults: A Cross-Sectional, Observational Study.Healthcare (Basel, Switzerland) · 2024Article
- Effect of Cognitive Decline on Mandibular Movement during Mastication in Nursing Home Residents.Journal of clinical medicine · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Masticatory function such as chewing is expected to modify human cognitive function, and/or the possibility of improving cognitive function is also predicted. This systematic review investigated whether masticatory function affects cognitive function for older/young adults. Full articles written in English from January 2000 to April 2022 were collected using PubMed and Cochrane Library. Target outcomes were cognitive function test scores, cognitive processing speed (reaction time), and masticatory function. For each research question, two independent reviewers conducted the search and screening, data extraction, quality assessment, and risk of bias assessment. The reviewers resolved any disagreements by discussion. From 226 articles retrieved, 20 were included in this review. Older adults with lower scores on the cognitive function test had lower masticatory performance, lower chewing ability, chewing difficulty, and decreased number of teeth. An increased risk of cognitive impairment was found in older adults with masticatory dysfunction. For young adults, gum chewing significantly reduced the processing speed of cognitive tasks compared to no gum chewing. Although most of the evidence included had a low level of evidence and a high risk of bias because of the research designs, the results still suggest that mastication may be a factor in improving cognitive function.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.