ReviewCureus2023
Giant Cell Tumour of Bone: A Comprehensive Review of Pathogenesis, Diagnosis, and Treatment.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 20 citations in OpenAlex.
- Optimal management of giant cell tumor in the tibial plateau: A case report on curettage and cement reinforcement.Radiology case reports · 2026Article
- Intraosseous tumours of the knee.Skeletal radiology · 2026Review
- Incidence of malignant transformation in giant cell tumor of bone following denosumab therapy: a systematic review and meta-analysis.Journal of bone oncology · 2026Review
- Giant Cell Tumor of the Distal Humerus: A Rare Location With a Good Response to Denosumab.Cureus · 2026Article
- A Rare Case of Giant Cell tumor of Bone in Distal Tibia.Journal of orthopaedic case reports · 2026Article
- Campanacci stage and cortical destruction predict functional outcomes in giant cell tumor of bone.Irish journal of medical science · 2026Article
- Clinical and Radiological Concordance of Bone Tumours Using Histopathology as the Gold Standard: A Pilot Study.Cureus · 2026Article
- Freezing nitrogen ethanol composite as an alternative to liquid nitrogen in giant cell tumor cryotherapy: a case report and literature review.International journal of surgery case reports · 2026Article
- Distal Ulna Excision for Giant Cell Tumor-Retrospective Functional Outcome and Recurrence Analysis from Single Tertiary Center.Indian journal of surgical oncology · 2026Article
- PDGFRA mediates the PI3K/AKT signaling pathway to regulate the growth and phenotype of GCTB tumor cells.International journal of clinical and experimental pathology · 2026Article
- Patient-specific osteoarticular reconstruction of the proximal tibia for giant cell tumor using a 3D-printed trabecular implant and hinged knee arthroplasty: a case report.Frontiers in medicine · 2026Article
- Brown tumor of mandible: A conundrum towards the diagnosis.Journal of oral and maxillofacial pathology : JOMFP · 2025Article
- Article
- Radical resection of a giant cell tumor of the distal ulna and reconstruction with a 3D-printed distal ulnar prosthesis: A case report.Medicine · 2025Article
- Molecular pathological insights into tumorigenesis and progression of giant cell tumor of bone.Journal of bone oncology · 2025Review
- Treatment of Extraosseous Giant Cell Tumor of Bone and Calcitriol-Mediated Hypercalcemia With Denosumab in Paget Disease.JCEM case reports · 2025Article
- Immunohistochemical Characterization of Feline Giant Cell Tumor of Bone (GCTb): What We Know and What We Can Learn from the Human Counterpart.Animals : an open access journal from MDPI · 2025Article
- Case Report: Trapdoor procedure combined with arthrodiastasis treating chondroblastoma of the femoral head in adolescents.Frontiers in pediatrics · 2025Article
- Giant cell tumor of the bone with fatal pulmonary metastasis: A case report.SAGE open medical case reports · 2025Article
- Pathological predictors for curettage and cementation outcome in proximal tibial giant cell tumors.Bioinformation · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The benign aggressive tumour known as a giant cell tumour of bone (GCTB) frequently affects the knee bones. Patients suffering from GCTB present with pain, swelling, joint effusion, loss of ability to bear weight on the involved extremity and a restriction in the range of motion of the afflicted joint may also exist, depending on the tumour's size. GCTB makes up 20% of benign skeletal tumours and 5% of all primary bone tumours. Although it has an equal distribution of the sexes, the majority reveal a higher frequency among women. Eighty per cent of GCTB instances were recorded in patients between the ages of 20 and 50 during the third decade. The femur, tibia and radius are where GCTB is most frequently discovered. Lesions can be rated using the Campanacci grading method based on the plain radiograph's results. Plain radiography, CT and MRI are used to diagnose the tumour. Surgery is the only curative treatment which is determined by the Campanacci grade and the tumour's location. Recurrence of GCTB is observed in about 25% of patients, with curettage being associated with rates as high as 50%. We evaluated the GCTB-related articles and summarised the developments in diagnosis, treatment and reducing risk of recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.