Evidence map›Paper›PMID 38021267›Full record

ArticleCurrent therapeutic research, clinical and experimental2023

A Combination of Gamma-Aminobutyric Acid, Glutamic Acid, Calcium, Thiamine, Pyridoxine, and Cyanocobalamin vs Ginger Extract in the Management of Chronic Motion Sickness: A Clinical Evaluation.

Carlos P Nunes, Claudio Rodrigues, Mendel Suchmacher, Claudia Regina Esteves, Karin Gonçalves, Hélio Rzetelna, Rafael V Rodrigues, Luciana Regina de Vasconcelos, Spyros G E Mezitis, Heros Rabelo and 5 more

Open access · goldAbstract read
In one paragraph

Article in Current therapeutic research, clinical and experimental, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Carlos P NunesCentro Universitário Serra Dos Órgãos, Rio de Janeiro, Brazil.
Claudio RodriguesCentro Universitário Serra Dos Órgãos, Rio de Janeiro, Brazil.
Mendel SuchmacherInstituto de Pós-graduação Médica Carlos Chagas, Rio de Janeiro, Brazil.
Claudia Regina EstevesCentro Universitário Serra Dos Órgãos, Rio de Janeiro, Brazil.
Karin GonçalvesUniversidade Federal Fluminense, Rio de Janeiro, Brazil.
Hélio RzetelnaUniversidade Estácio de Sá. Faculdade de Medicina, RJ, Rio de Janeiro, Brazil.
Rafael V RodriguesClínica Otorrinolaringológica, Rio de Janeiro, Brazil.
Luciana Regina de VasconcelosClínica Otorrinolaringológica, Rio de Janeiro, Brazil.
Spyros G E MezitisCornell University Medical School, New York, NY.
Heros RabeloInstituto Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Renato KaufmannInstituto Estadual de Cardiologia Aloysio de Carvalho, Rio de Janeiro, Brazil.
Fernanda SchwarzUniversidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Henrique GoldbergUniversidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil.
Aline SintoveterUNIFESO School of Medicine, Rio de Janeiro, Brazil.
Mauro GellerCentro Universitário Serra Dos Órgãos, Rio de Janeiro, Brazil.
Centro Universitário Serra dos Órgãos · BRInstituto Brasiliense de Otorrinolaringologia · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal do Rio de Janeiro · BRCornell University · USFundação Carlos Chagas · BRFundação Oswaldo Cruz · BRInstituto Nacional de Cardiologia · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Motion sickness (kinetosis) is a common and temporarily incapacitant ailment, manageable with behavioral as well as pharmacological measures. Objective: To assess the effectiveness and safety of a combination of gamma-aminobutyric acid, glutamic acid, calcium, thiamine, pyridoxine, and cyanocobalamin (Group A) (n = 170) and extract of Methods: Both groups were tested according to the following end points, under self-paired as well as comparative study designs: reduction of ≥20 score points in the total motion sickness assessment questionnaire (MSAQ) score, percentage of patients presenting a reduction of the total MSAQ score, absolute MSAQ score reduction, physician's assessment scores, final overall assessment of study medication, and willingness to continue treatment. Safety was also evaluated. Results: There was a statistically significant better performance under both study designs for Group A ( Conclusions: Group A and Group B regimens were effective and safe in the management of chronic complaints consistent with motion sickness and the Group A regimen was more effective than Group B.

Indexed as

Gamma-aminobutyric acid tartrate and associationsGingerMotion sickness

Identifiers

PMID38021267
PMCPMC10630771
OpenAlexW4387369679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.