Evidence map›Paper›PMID 38021221›Full record

ArticleFrontiers in human neuroscience2023

Use of non-invasive transcutaneous auricular vagus nerve stimulation: neurodevelopmental and sensory follow-up.

Turki Aljuhani, Patricia Coker-Bolt, Lakshmi Katikaneni, Viswanathan Ramakrishnan, Alyssa Brennan, Mark S George, Bashar W Badran, Dorothea Jenkins

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07049952 (BabyStrong II), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07049952 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

BabyStrong II (Stimulating the Tragus for Neural Growth): A Randomized Controlled Trial of taVNS-Paired Bottle Feeding to Improve Oral Feeding

TypeinterventionalSponsorMedical University of South CarolinaRan2025 to 2027Enrolled88ConditionsFeeding Delays, Neonates and Term InfantsArmstaVNS, NAC and taVNS, inactive taVNS, sterile water and inactive taVNS
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Turki AljuhaniDivision of Health Science and Research, Medical University of South Carolina, Charleston, SC, United States.
Patricia Coker-BoltDoctorate of Occupational Therapy Program, Hawai'i Pacific University, Honolulu, HI, United States.
Lakshmi KatikaneniDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States.
Viswanathan RamakrishnanDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
Alyssa BrennanDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States.
Mark S GeorgeDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Bashar W BadranDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States.
Dorothea JenkinsDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, United States.
Medical University of South Carolina · USHawaii Pacific University · USRalph H. Johnson VA Medical Center · US

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Techniques DevelopmentP2CHD086844 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GEORGE, MARK S · 2015 to 2024
$12.7M
NICHD NIH HHS P2C HD086844NIGMS NIH HHS P20 GM109040
6 · The paper itself

Abstract

Objective: To assess the impact of non-invasive transcutaneous auricular vagal nerve stimulation (taVNS) paired with oral feeding on long-term neurodevelopmental and sensory outcomes. Method: We tested 21 of 35 children who as infants were gastrostomy tube (G-tube) candidates and participated in the novel, open-label trial of taVNS paired with oral feeding. To evaluate possible effects on development at 18-months after infant taVNS, we performed the Bayley-III ( Results: At a mean of 19-months, taVNS 'responders' showed significantly better general sensory processing on the SP-2 than 'non-responders'. There were no differences in other test scores, which were similar to published outcomes for infants who required G-tubes. Conclusion: This is the first report of neurodevelopmental follow-up in infants who received taVNS-paired feeding. They had similar developmental outcomes as historical control infants failing oral feeds who received G-tubes. Our data suggests that infants who attained full oral feeds had better sensory processing.

Indexed as

feeding delayinfantsneurodevelopmental delaysensory processingtaVNS

Identifiers

PMID38021221
PMCPMC10666166
OpenAlexW4388636199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.