Evidence map›Paper›PMID 38021172›Full record

ArticlemicroPublication biology2023

Changing the phospholipid composition of lipid droplets alters localization of select lipid droplet proteins.

Timothy J Renier, Olivia R Paetz, Matthew C Paal, Alex B Long, Margaret R Brown, Sunny H Vuong, Sathish Kumar Perumal, Kusum K Kharbanda, Laura L Listenberger

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Timothy J Renier *Departments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Olivia R Paetz *Departments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Matthew C PaalDepartments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Alex B LongDepartments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Margaret R BrownDepartments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Sunny H VuongDepartments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
Sathish Kumar PerumalResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska, United States.
Kusum K Kharbanda *Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, Nebraska, United States.
Laura L Listenberger *Departments of Biology and Chemistry, St. Olaf College, Northfield, Minnesota, United States.
St. Olaf College · USNebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and HeartP50AA030407 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Kusum K. Kharbanda · 2023 to 2026
$7.9M
Impaired phospholipid methylation results in decreased lipid droplet lipolysis: Role in hepatic steatosisR01AA026723 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2018 to 2022
$1.6M
Impaired methylation alters lipid droplet dynamics in liver and adipose tissue: Role in hepatic steatosisI01BX004053 · VA · OMAHA VA MEDICAL CENTER · PI KHARBANDA, KUSUM K. · 2019 to 2023
–
Gut-Liver Axis in the Pathogenesis of Alcohol-Associated Liver Disease: Protection by Betaine TreatmentI01BX006064 · VA · OMAHA VA MEDICAL CENTER · PI Kusum K. Kharbanda · 2024 to 2026
–
BLRD VA I01 BX001155BLRD VA I01 BX004053BLRD VA I01 BX006064NIAAA NIH HHS P50 AA030407NIAAA NIH HHS R01 AA026723
6 · The paper itself

Abstract

Our experiments aim to determine if decreasing the amount of phosphatidylcholine (PC) relative to phosphatidylethanolamine (PE) at the lipid droplet surface changes the localization of specific lipid droplet proteins. We manipulate lipid droplet phospholipids in both a cultured mouse hepatocyte (AML12) cell line and on synthetic lipid droplets. Decreasing the PC:PE ratio increases perilipin 2, decreases DGAT2, and does not change rab18 or lanosterol synthase levels on lipid droplets. These differences may be explained by the distinct structural motifs that mediate the protein-lipid droplet interactions.

Identifiers

PMID38021172
PMCPMC10656625
OpenAlexW4389179212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.