Evidence map›Paper›PMID 38021121›Full record

ArticleBiomedical optics express2023

Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy.

Kyle R Cowdrick, Mariam Akbar, Tisha Boodooram, LaBeausha H Harris, Shasha Bai, Rowan O Brothers, Michael Arrington, Seung Yup Lee, Kirsma Khemani, Beatrice Gee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kyle R CowdrickWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-2236-6137
Mariam AkbarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
Tisha BoodooramWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
LaBeausha H HarrisWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
Shasha BaiPediatric Biostatistics Core, Emory University School of Medicine, 1405 Clifton Road NE, Atlanta, GA 30322, USA.
Rowan O BrothersWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
Michael ArringtonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
Seung Yup LeeDepartment of Electrical and Computer Engineering, Kennesaw State University, 840 Polytechnic Lane, Marietta, GA 30060, USA.ORCID https://orcid.org/0000-0002-0530-8464
Kirsma KhemaniAflac Cancer and Blood Disorders Center, Division of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Beatrice GeeAflac Cancer and Blood Disorders Center, Division of Pediatric Hematology/Oncology, Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Erin M BuckleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Drive NE, Atlanta, GA 30322, USA.
The Wallace H. Coulter Department of Biomedical Engineering · USEmory University · USKennesaw State University · US

Funding

Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell diseaseR01HL152322 · NHLBI · EMORY UNIVERSITY · PI BUCKLEY, ERIN MCGUIRE, GEE, BEATRICE E · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL152322
6 · The paper itself

Abstract

Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response to a vasodilatory stimulus, is an integral mechanism in brain homeostasis that is thought to be impaired in sickle cell disease (SCD). This study used diffuse correlation spectroscopy and a simple breath-hold stimulus to quantify CVR non-invasively in a cohort of 12 children with SCD and 14 controls. Median [interquartile range] CVR was significantly decreased in SCD compared to controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide a feasible means to routinely monitor CVR impairments in pediatric SCD.

Identifiers

PMID38021121
PMCPMC10659811
OpenAlexW4387185684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.