Evidence map›Paper›PMID 38021113›Full record

ArticleBiomedical optics express2023

Nanobomb optical coherence elastography in multilayered phantoms.

Maryam Hatami, Dmitry Nevozhay, Manmohan Singh, Alexander Schill, Paul Boerner, Salavat Aglyamov, Konstantin Sokolov, Kirill V Larin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maryam HatamiDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.
Dmitry NevozhayDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Manmohan SinghDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.ORCID https://orcid.org/0000-0002-8396-5451
Alexander SchillDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.
Paul BoernerDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.
Salavat AglyamovDepartment of Mechanical Engineering, University of Houston, Houston, Texas 77204, USA.ORCID https://orcid.org/0000-0001-9530-1225
Konstantin SokolovDepartment of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.ORCID https://orcid.org/0000-0002-0198-2005
Kirill V LarinDepartment of Biomedical Engineering, University of Houston, Houston, Texas 77204, USA.ORCID https://orcid.org/0000-0002-5532-5027

Funding

Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
Biomechanics of accommodationR01EY030063 · NEI · UNIVERSITY OF HOUSTON · PI LARIN, KIRILL V, MANNS, FABRICE · 2020 to 2024
$3.0M
No-Touch High Resolution Optical Coherence Elastography of the Cornea using a HeartbeatR01EY033978 · NEI · UNIVERSITY OF HOUSTON · PI Kirill V Larin · 2022 to 2026
$2.9M
3D Imaging of Tumor Mechanobiology Using Nanobomb Optical Coherence ElastographyR21CA231561 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOKOLOV, KONSTANTIN V · 2019 to 2020
$389k
NCI NIH HHS R21 CA231561NEI NIH HHS R01 EY022362NEI NIH HHS R01 EY030063NEI NIH HHS R01 EY033978
6 · The paper itself

Abstract

Many tissues are composed of layered structures, and a better understanding of the changes in the layered tissue biomechanics can enable advanced guidance and monitoring of therapy. The advent of elastography using longitudinally propagating shear waves (LSWs) has created the prospect of a high-resolution assessment of depth-dependent tissue elasticity. Laser activation of liquid-to-gas phase transition of dye-loaded perfluorocarbon (PFC) nanodroplets (a.k.a., nanobombs) can produce highly localized LSWs. This study aims to leverage the potential of photoactivation of nanobombs to incudce LSWs with very high-frequency content in wave-based optical coherence elastography (OCE) to estimate the elasticity gradient with high resolution. In this work, we used multilayered tissue-mimicking phantoms to demonstrate that highly localized nanobomb (NB)-induced LSWs can discriminate depth-wise tissue elasticity gradients. The results show that the NB-induced LSWs rapidly change speed when transitioning between layers with different mechanical properties, resulting in an elasticity resolution of ∼65 µm. These results show promise for characterizing the elasticity of multilayer tissue with a fine resolution.

Identifiers

PMID38021113
PMCPMC10659790

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.