ArticleCell genomics2023
Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- The Non-Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases.medRxiv : the preprint server for health sciences · 2025Article
- High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus.Nature communications · 2024Article
- TRAF1 Deficiency in Macrophages Drives Exacerbated Joint Inflammation in Rheumatoid Arthritis.Biomolecules · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
26 authors at 9 institutions in 4 countries.
Qiang WangDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Marta Martínez-BonetDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Taehyeung KimDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jeffrey A SparksDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kazuyoshi IshigakiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiaoting ChenCenter of Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Marc SudmanCenter of Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Vitor AguiarDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Sangwan SimDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Marcos Chiñas HernandezDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Darren J ChiuDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alexandra WactorDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Brian WaufordDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Miranda C MarionDepartment of Biostatistics and Data Science, and Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Maria Gutierrez-ArcelusDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
John BowesCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, UK.
Stephen EyreCentre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, UK.
Ellen NordalUniversity Hospital of North Norway and UIT The Arctic University of Norway, Tromsø, Norway.
Sampath PrahaladEmory University Department of Pediatrics and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Marite RyggDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Vibeke VidemDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Soumya RaychaudhuriDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Matthew T WeirauchCenter of Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Carl D LangefeldDepartment of Biostatistics and Data Science, and Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Susan D ThompsonCenter of Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Peter A NigrovicDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Boston Children's Hospital · USBrigham and Women's Hospital · USCincinnati Children's Hospital Medical Center · USManchester Academic Health Science Centre · GBNorwegian University of Science and Technology · NOWake Forest University · USBroad Institute · USEmory University · USUniversity Hospital of North Norway · NO
Funding
VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYticsP30AR072577 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel Hal Solomon · 2017 to 2026
$9.8MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MThe Next Generation Immunoanalysis CoreP30AR069625 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2016 to 2025
$8.8MHLA GENE COMPLEMENTATION IN PRIMARY SJOGREN'S AND LUPUSR01AI024717 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KOTTYAN, LEAH CLAIRE, WEIRAUCH, MATTHEW TYSON · 1987 to 2025
$7.8MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Grant Sanford Schulert · 2016 to 2026
$7.7MGene Regulation as a Foundation for Autoimmune Disease PreventionU01AI130830 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2017 to 2021
$7.2MDiscovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4MBinding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsR01NS099068 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, Matthew Tyson Weirauch · 2017 to 2026
$4.2MLy6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0MRheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung DiseaseR01AR077607 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SPARKS, JEFFREY ANDREW · 2021 to 2025
$3.7MBridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2MIdentifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIAR01HD089928 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BECKER, MARA LEIGH, THOMPSON, SUSAN D · 2017 to 2021
$2.8MNHGRI NIH HHS R01 HG010730NIAID NIH HHS R01 AI024717NIAID NIH HHS U01 AI130830NIAMS NIH HHS P30 AR069625NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR070549NIAMS NIH HHS P30 AR072577NIAMS NIH HHS R01 AR063759NIAMS NIH HHS R01 AR065538NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01 AR073228NIAMS NIH HHS R01 AR075906NIAMS NIH HHS R01 AR077607NICHD NIH HHS R01 HD089928NINDS NIH HHS R01 NS099068
Abstract
PubMed holds no abstract for this paper.
Indexed as
C5FRA2genome-wide association studyjuvenile idiopathic arthritismonocytenon-coding variantrheumatoid arthritisTNFTRAF1
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.