Evidence map›Paper›PMID 38020974›Full record

ArticleCell genomics2023

Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast

Laura H McCulloch, Vijayan Sambasivam, Amanda L Hughes, Narayana Annaluru, Sivaprakash Ramalingam, Viola Fanfani, Evgenii Lobzaev, Leslie A Mitchell, Jitong Cai, Build-A-Genome Class and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  6. Recent technology advancements in large-scale DNA assembly.Quantitative biology (Beijing, China) · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Laura H McCullochInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Vijayan SambasivamDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Amanda L HughesEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Narayana AnnaluruDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Sivaprakash RamalingamDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Viola FanfaniSchool of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK.
Evgenii LobzaevSchool of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK.
Leslie A MitchellInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Jitong CaiDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Build-A-Genome Class
Hua JiangLaboratory of Cellular and Structural Biology, Rockefeller University, New York, NY 10065, USA.
John LaCavaLaboratory of Cellular and Structural Biology, Rockefeller University, New York, NY 10065, USA.
Martin S TaylorDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
William R BishaiDepartment of Medicine/Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Giovanni StracquadanioSchool of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK.
Lars M SteinmetzEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69117 Heidelberg, Germany.
Joel S BaderDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Weimin ZhangInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.
Srinivasan ChandrasegaranDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Funding

Elucidating structural, mechanistic, and allosteric determinants of mTOR Complex 2 (mTORC2) signaling.K08DK129824 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI TAYLOR, MARTIN S · 2021 to 2025
$853k
NIDDK NIH HHS K08 DK129824
6 · The paper itself

Abstract

We describe the complete synthesis, assembly, debugging, and characterization of a synthetic 404,963 bp chromosome,

Indexed as

centromere destabilizationchromoductionchromosome debuggingchromosome substitutionEST3megachunk assemblySaccharomyces cerevisiaesynIXtranscriptomics

Identifiers

PMID38020974
PMCPMC10667316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.