Evidence map›Paper›PMID 38020971›Full record

ArticleCell genomics2023

Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics.

Benjamin A Blount, Xinyu Lu, Maureen R M Driessen, Dejana Jovicevic, Mateo I Sanchez, Klaudia Ciurkot, Yu Zhao, Stephanie Lauer, Robert M McKiernan, Glen-Oliver F Gowers and 14 more

Abstract read
In one paragraph

Article in Cell genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  11. Recent technology advancements in large-scale DNA assembly.Quantitative biology (Beijing, China) · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Evolution and synthetic biology.Current opinion in microbiology · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Benjamin A BlountImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Xinyu LuImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Maureen R M DriessenImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Dejana JovicevicImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Mateo I SanchezImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Klaudia CiurkotImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Yu ZhaoInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Stephanie LauerInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Robert M McKiernanImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Glen-Oliver F GowersImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Fiachra SweeneyImperial College Centre for Synthetic Biology, Imperial College London, London, UK.
Viola FanfaniSchool of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Evgenii LobzaevSchool of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Kim Palacios-FloresLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Querétaro, México.
Roy S K WalkerSchool of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh, UK.
Andy HeskethDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Jitong CaiDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Stephen G OliverDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Yizhi CaiSchool of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Giovanni StracquadanioSchool of Biological Sciences, The University of Edinburgh, Edinburgh, UK.
Leslie A MitchellInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Joel S BaderDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY, USA.
Tom EllisImperial College Centre for Synthetic Biology, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe construction of the synthetic yeast chromosome XI (

Indexed as

eccDNAextrachromosomal circular DNAgenome editingSc2.0stress adaptationsynthetic biologysynthetic genomicsYeast 2.0

Identifiers

PMID38020971
PMCPMC10667340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.