Evidence map›Paper›PMID 38020910›Full record

ArticleFrontiers in cell and developmental biology2023

p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK.

Bo Xie, Hongyan Yuan, Xuqiang Zou, Mingjie Lu, Yixin Zhang, Dan Xu, Xuelian Peng, Di Wang, Manzhu Zhao, Xiujie Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Bo Xie *Department of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Hongyan Yuan *Department of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Xuqiang ZouDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Mingjie LuDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Yixin ZhangDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Dan XuDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Xuelian PengDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Di WangChongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing, China.
Manzhu ZhaoChongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, College of Stomatology, Chongqing Medical University, Chongqing, China.
Xiujie WenDepartment of Orthodontics, School of Stomatology, Southwest Medical University, Luzhou, China.
Southwest Medical University · CNChongqing Medical University · CNStomatological Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The circadian clock plays a critical role in dentomaxillofacial development. Tooth biomineralization is characterized by the circadian clock; however, the mechanisms underlying the coordination of circadian rhythms with tooth development and biomineralization remain unclear. The p75 neurotrophin receptor (p75NTR) is a clock factor that regulates the oscillatory components of the circadian rhythm. This study aims to investigate the impact of p75NTR on the rhythmic mineralization of teeth and elucidate its underlying molecular mechanisms. We generated p75NTR knockout mice to examine the effects of p75NTR deficiency on tooth mineralization. Ectomesenchymal stem cells (EMSCs), derived from mouse tooth germs, were used for

Indexed as

circadian rhythmectomesenchymal stem cellsmineralizationodontogenic differentiationp75NTRtooth development

Identifiers

PMID38020910
PMCPMC10662321
OpenAlexW4388458539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.