ArticleFrontiers in aging neuroscience2023
DNA methylation of the oxytocin receptor interacts with age to impact neural response to social stimuli.
Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- Unraveling the impact of oxytocin receptor gene methylation on stress and inflammation in older adults.Journal of neuroendocrinology · 2026Article
- Interplay of plasma Oxytocin and oxytocin receptor gene methylation levels on empathy in older adults.Scientific reports · 2025Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
Introduction: Social isolation is one of the strongest predictors of increased risk of mortality in older adulthood. The ability to form and maintain the social relationships that mitigate this risk is partially regulated by the oxytocinergic system and one's ability to attend to and process social information. We have previously shown that an epigenetic change to the DNA of the oxytocin receptor gene ( Methods: Here we explored age-related differences in the association between neural response during selective social attention and Results and Discussion: We found that older adults activated diffuse areas of visual cortex and dorsolateral prefrontal cortex during selective social attention, consistent with the dedifferentiation and compensatory neural activation commonly reported in aging. We found a significant age-by-
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