Evidence map›Paper›PMID 38020779›Full record

ArticleFrontiers in aging neuroscience2023

Associations between circulating cardiovascular disease risk factors and cognitive performance in cognitively healthy older adults from the NuAge study.

Noah D Koblinsky, Pierre-Hugues Carmichael, Sylvie Belleville, Alexandra J Fiocco, Pierrette Gaudreau, Carol E Greenwood, Marie-Jeanne Kergoat, José A Morais, Nancy Presse, Danielle Laurin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noah D KoblinskyRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Pierre-Hugues CarmichaelCenter d'excellence sur le Vieillissement de Québec, Center de Recherche du Center Hospitalier Universitaire (CHU) de Québec-Université Laval and VITAM-Center de Recherche en Santé Durable, Center Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de la Capitale Nationale, Québec, QC, Canada.
Sylvie BellevilleCenter de Recherche de l'Institut Universitaire de Gériatrie de Montréal, CIUSSS du Center-Sud-de-l'Île-de-Montréal, Montreal, QC, Canada.
Alexandra J FioccoDepartment of Psychology, Toronto Metropolitan University, Toronto, ON, Canada.
Pierrette GaudreauCenter de Recherche du Center Hospitalier de l'Université de Montréal and Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
Carol E GreenwoodRotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada.
Marie-Jeanne KergoatDépartement de Médecine, Université de Montréal, Montreal, QC, Canada.
José A MoraisDivision of Geriatrics, McGill University, Montreal, QC, Canada.
Nancy PresseCenter de Recherche du Center Hospitalier de l'Université de Montréal and Faculté de Médecine, Université de Montréal, Montreal, QC, Canada.
Danielle LaurinCenter d'excellence sur le Vieillissement de Québec, Center de Recherche du Center Hospitalier Universitaire (CHU) de Québec-Université Laval and VITAM-Center de Recherche en Santé Durable, Center Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de la Capitale Nationale, Québec, QC, Canada.
Guylaine FerlandMontreal Heart Institute Research Center, and Département de Nutrition, Université de Montréal, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cardiovascular disease risk factors (CVRFs) contribute to the development of cognitive impairment and dementia. Methods: This study examined the associations between circulating CVRF biomarkers and cognition in 386 cognitively healthy older adults (mean age = 78 ± 4 years, 53% females) selected from the Quebec Longitudinal Study on Nutrition and Successful Aging (NuAge). Memory, executive function, and processing speed were assessed at baseline and 2-year follow-up. CVRF biomarkers included total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides, glucose, insulin, high sensitivity C-reactive protein (hs-CRP), homocysteine, protein carbonyls, and cortisol. Linear mixed models were used to determine associations between individual CVRF biomarkers and cognition at both time points. Results: HDL-C was most consistently associated with cognition with higher values related to better performance across several domains. Overall, stronger and more consistent relationships between CVRF biomarkers and cognition were observed in females relative to males. Discussion: Findings suggest that increases in the majority of circulating CVRFs are not associated with worse cognition in cognitively healthy older adults.

Indexed as

cardiovascular risk factorscognitioncognitively healthyHDLolder adults

Identifiers

PMID38020779
PMCPMC10668121

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.