Evidence map›Paper›PMID 38020728›Full record

ArticleClinical & translational immunology2023

Antibody glycosylation correlates with disease progression in SIV-

Ebene R Haycroft, Timon Damelang, Ester Lopez, Mark A Rodgers, Bruce D Wines, Mark Hogarth, Cassaundra L Ameel, Stephen J Kent, Charles A Scanga, Shelby L O'Connor and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Antigen specificity shapes antibody functions in tuberculosis.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ebene R HaycroftDepartment of Microbiology and Immunology Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC Australia.
Timon DamelangDepartment of Microbiology and Immunology Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC Australia.
Ester LopezDepartment of Microbiology and Immunology Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC Australia.
Mark A RodgersDepartment of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Pittsburgh PA USA.
Bruce D WinesImmune Therapies Group Burnet Institute Melbourne VIC Australia.
Mark HogarthImmune Therapies Group Burnet Institute Melbourne VIC Australia.
Cassaundra L AmeelDepartment of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Pittsburgh PA USA.
Stephen J KentDepartment of Microbiology and Immunology Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC Australia.ORCID https://orcid.org/0000-0002-8539-4891
Charles A ScangaDepartment of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Pittsburgh PA USA.
Shelby L O'ConnorDepartment of Pathology and Laboratory Medicine University of Wisconsin-Madison Madison WI USA.
Amy W ChungDepartment of Microbiology and Immunology Doherty Institute for Infection and Immunity The University of Melbourne Melbourne VIC Australia.ORCID https://orcid.org/0000-0003-0020-9704
The University of Melbourne · AUUniversity of Pittsburgh · USBurnet Institute · AUUniversity of Wisconsin System · US

Funding

The Impact of Pre-exisiting SIV on Host Immunity to M tuberculosis in MacaquesR01AI111815 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCANGA, CHARLES A. · 2015 to 2019
$3.8M
NIAID NIH HHS R01 AI111815
6 · The paper itself

Abstract

Objectives: Tuberculosis (TB) remains a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (HIV) worldwide. However, the immunological mechanisms associated with the enhanced susceptibility among HIV-positive individuals remain largely unknown. Methods: Here, we used a simian immunodeficiency virus (SIV)/TB-coinfection Mauritian cynomolgus macaque (MCM) model to examine humoral responses from the plasma of SIV-negative ( Results: Antibody responses to Conclusion: These studies suggest that humoral immunity may contribute to control of TB disease and support growing literature that highlights antibody Fc glycosylation as a biomarker of TB disease progression.

Indexed as

antibodiescynomolgus macaquesFcglycosylationSIVtuberculosis

Identifiers

PMID38020728
PMCPMC10660403
OpenAlexW4388927194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.