Evidence map›Paper›PMID 38020716›Full record

ArticleMedComm2023

Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism.

Kang Chen, Fei Tang, Bin Du, Zhe-Zhou Yue, Ling-Ling Jiao, Xu-Long Ding, Qing-Zhang Tuo, Jie Meng, Si-Yu He, Lunzhi Dai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kang ChenDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Fei TangDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Bin DuDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Zhe-Zhou YueGuizhou Yiluoqini Techno. Co., Ltd, Guizhou Shuanglong Airport Economic Zone Guiyang P. R. China.
Ling-Ling JiaoDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Xu-Long DingDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Qing-Zhang TuoDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Jie MengDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Si-Yu HeDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.
Lunzhi DaiDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.ORCID https://orcid.org/0000-0002-3003-8910
Peng LeiDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.ORCID https://orcid.org/0000-0001-5652-1962
Xia-Wei WeiDepartment of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital, Sichuan University, and Collaborative Center for Biotherapy Chengdu P. R. China.ORCID https://orcid.org/0000-0002-6513-6422
Sichuan University · CNWengFu Group (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in

Indexed as

A53TLRRK2MAP1BMPTPParkinson's disease

Identifiers

PMID38020716
PMCPMC10661827
OpenAlexW4388851137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.