ReviewFrontiers in neurology2023
Mechanisms associated with post-stroke depression and pharmacologic therapy.
Review in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Acupuncture therapies for post-stroke depression: the evidence mapping of clinical studies.Frontiers in psychiatry · 2025Pooled it
- Acupuncture combined with repetitive transcranial magnetic stimulation for the treatment of post-stroke depression: a systematic evaluation and meta-analysis based on a randomised controlled trial.Frontiers in neurology · 2024Pooled it
- Basic and clinical research on acupuncture for post-stroke depression: A narrative review.World journal of methodology · 2026Review
- The Therapeutic Potential of Mesenchymal Stem Cells in Post-Stroke Depression.International journal of molecular sciences · 2026Review
- Person-Centered Approaches for Identifying Subgroups of Post-Stroke Depression: A Systematic Review of Observational Studies.Patient preference and adherence · 2026Review
- Post-intracerebral hemorrhage depression comorbid with obstructive sleep apnea and REM sleep behavior disorder: a case report and literature review.Frontiers in psychiatry · 2026Article
- Neuropharmacological Insights into Glutamate Homeostasis in Post-stroke Depression Regulated by Astrocytes.Current neuropharmacology · 2026Review
- Predicting Post-Stroke Depression Risk in Elderly Patients Based on Machine Learning: A Retrospective Cohort Study Integrating Neuroimaging and Psychosocial Variables.Neuropsychiatric disease and treatment · 2026Article
- Hyperbaric Oxygen Therapy Upregulates Neurotrophic Factors to Ameliorate Post-Stroke Depression: A Randomized Sham-Controlled Trial.Neuropsychiatric disease and treatment · 2026Article
- Differential Effects of Murine Stroke Models on Dopaminergic Neurons, Glial Responses, and Neurobehavioral Outcomes.Translational stroke research · 2025Article
- Stroke Survivors Have Almost Three Times Higher Risk of Depression: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Acupuncture and Moxibustion for Poststroke Depression: Systematic Review.Interactive journal of medical research · 2025Review
- Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome.Journal of the American Heart Association · 2025Article
- Prevalence and Associated Factors of Depression in Patients with Ischaemic Stroke: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2025Article
- Modulating Gut Microbiota: The Mechanism of Electroacupuncture at the "Siguan" Acupoints in Alleviating Post-Stroke Depression.Neuropsychiatric disease and treatment · 2025Article
- Rate of Post-Stroke Depression and Associated Factors in Saudi Single Tertiary Medical Center.Journal of multidisciplinary healthcare · 2025Article
- Ketamine in post-stroke depression: a report of 2 cases.Frontiers in psychiatry · 2025Article
- Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis.Aging clinical and experimental research · 2024Article
- Mechanism of Treadmill Exercise Combined with Rich Environmental Stimulation to Improve Depression in Post-stroke Depression Model Rats.Actas espanolas de psiquiatria · 2024Article
- Post-stroke emotionalism: Diagnosis, pathophysiology, and treatment.International journal of stroke : official journal of the International Stroke Society · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD. Neuroinflammation, neuroendocrinology, neurotrophic factors, and the site of the stroke lesion may affect neurotransmitters. Thus the mechanisms of PSD have been increasingly studied. Pharmacological treatment mainly includes SSRIs, noradrenergic and specific serotonergic antidepressant (NaSSA), anti-inflammatory drugs, vitamin D, ect, which have been confirmed to have better efficacy by clinical studies. Currently, there is an increasing number of studies related to the mechanisms of PSD. However, the mechanisms and pharmacologic treatment of PSD is still unclear. In the future, in-depth research on the mechanisms and treatment of PSD is needed to provide a reference for the prevention and treatment of clinical PSD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.