Evidence map›Paper›PMID 38020274›Full record

ArticleJournal of public health in Africa2023

Genotypic resistance testing improves antiretroviral treatment outcomes in a cohort of adolescents in Cameroon: Implications in the dolutegravir-era.

Willy LE Roi Togna Pabo, Debimeh Njume, Roland Ndip Ndip, Désiré Takou, Maria-Mercedes Santoro, Collins Chenwi, Grace Beloumou, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Aude Christelle Ka'e and 13 more

Open access · goldAbstract read
In one paragraph

Article in Journal of public health in Africa, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Willy LE Roi Togna Pabo
Debimeh NjumeChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Roland Ndip NdipFaculty of Science, University of Buea, Buea.
Désiré TakouChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Maria-Mercedes SantoroUniversity of Rome Tor Vergata, Rome, Italy.
Collins ChenwiChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Grace BeloumouChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Ezechiel Ngoufack Jagni SemengueChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Alex Durand NkaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Aude Christelle Ka'eChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Georges TetoChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Beatrice DambayaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Sandrine DjupsaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Raymond Babila NyasaFaculty of Science, University of Buea, Buea.
Davy Hyacinthe Gouissi AnguechiaChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Cedric KamtaMfou District Hospital, Mfou.
Lionel BalaMbalmayo District Hospital, Mbalmayo.
Virginie LamboNkomo Integrated Health Center, Nkomo, Cameroon.
Samuel Martin SossoChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Vittorio ColizziChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Carlo Federico PernoChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Joseph FokamChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Alexis NdjoloChantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé.
Centre International De Reference Chantal Biya · CMUniversité de Yaoundé I · CMUniversity of Rome Tor Vergata · ITUniversity of Buea · CMMonterey Bay Aquarium Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired drug resistance (ADR) is common among adolescents living with perinatal HIV (APHI) in sub-Saharan Africa (SSA). Personalized management has the potential to improve pediatric antiretroviral therapy (ART), even in the presence of long-term treatment and HIV-1 subtype diversity. We sought to evaluate the effect of HIV-1 mutational profiling on immuno-virological response and ADR among APHI. A cohort-study was conducted from 2018-2020 among 311 APHI receiving ART in Cameroon. Clinical, immunological and virological responses were measured at enrolment (T1), 6-months (T2) and 12-months (T3). Immunological failure (IF: CD4 #x003C;250 cells/mm

Indexed as

adolescentsantiretroviral therapyCameroonHIV careHIV drug resistanceviral load

Identifiers

PMID38020274
PMCPMC10658463
OpenAlexW4388898839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.