Evidence map›Paper›PMID 38020071›Full record

ArticleRSC medicinal chemistry2023

Synthesis of 2-aminopropyl benzopyran derivatives as potential agents against triple-negative breast cancer.

Ainhoa García, Sandra Torres-Ruiz, Laura Vila, Carlos Villarroel-Vicente, Álvaro Bernabeu, Pilar Eroles, Nuria Cabedo, Diego Cortes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ainhoa GarcíaDepartment of Pharmacology, University of Valencia 46100 Valencia Spain ncabedo@uv.es.ORCID https://orcid.org/0000-0001-8561-6311
Sandra Torres-RuizInstitute of Health Research-INCLIVA, University Clinic Hospital of Valencia 46010 Valencia Spain.
Laura VilaInstitute of Health Research-INCLIVA, University Clinic Hospital of Valencia 46010 Valencia Spain.ORCID https://orcid.org/0000-0002-7729-6060
Carlos Villarroel-VicenteDepartment of Pharmacology, University of Valencia 46100 Valencia Spain ncabedo@uv.es.
Álvaro BernabeuDepartment of Pharmacology, University of Valencia 46100 Valencia Spain ncabedo@uv.es.
Pilar ErolesInstitute of Health Research-INCLIVA, University Clinic Hospital of Valencia 46010 Valencia Spain.
Nuria CabedoDepartment of Pharmacology, University of Valencia 46100 Valencia Spain ncabedo@uv.es.ORCID https://orcid.org/0000-0001-6729-8057
Diego CortesDepartment of Pharmacology, University of Valencia 46100 Valencia Spain ncabedo@uv.es.ORCID https://orcid.org/0000-0001-9158-1426
Universitat de València · ESINCLIVA Health Research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesis of three series of 2-aminopropyl derivatives containing a benzopyran nucleus was performed to evaluate their performance against triple-negative breast cancer cell lines (MDA-MB-231 and MDA-MB-436) and normal breast epithelial cells (MCF10A). For the three series, the cytotoxic activity was as follows:

Identifiers

PMID38020071
PMCPMC10650959
OpenAlexW4387350110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.