ArticleRSC advances2023
Achieving high hybridization density at DNA biosensor surfaces using branched spacer and click chemistry.
Article in RSC advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Chronocoulometric Quantification of DNA Surface Coverage on Electrochemically Functionalized MoSACS measurement science au · 2026Article
- "Grafting-from" and "Grafting-to" Poly(N-isopropyl acrylamide) Functionalization of Glass for DNA Biosensors with Improved Properties.Polymers · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
The COVID-19 pandemic has highlighted the necessity to develop fast, highly sensitive and selective virus detection methods. Surface-based DNA-biosensors are interesting candidates for this purpose. Functionalization of solid substrates with DNA must be precisely controlled to achieve the required accuracy and sensitivity. In particular, achieving high hybridization density at the sensing surface is a prerequisite to reach a low limit of detection. We herein describe a strategy based on peptides as anchoring units to immobilize DNA probes at the surface of borosilicate slides. While the coating pathway involves copper-catalyzed click chemistry, a copper-free variation is also reported. The resulting biochips display a high hybridization density (2.9 pmol per cm
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