Evidence map›Paper›PMID 38019934›Full record

ArticleScience translational medicine2023

Resident microbes shape the vaginal epithelial glycan landscape.

Kavita Agarwal, Biswa Choudhury, Lloyd S Robinson, Sydney R Morrill, Yasmine Bouchibiti, Daisy Chilin-Fuentes, Sara B Rosenthal, Kathleen M Fisch, Jeffrey F Peipert, Carlito B Lebrilla and 3 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. mSystems · 2025
    Article
  6. Sialidases derived frombioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Hallmarks of Bacterial Vaginosis.Diagnostics (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Review
  14. Characterization ofFrontiers in microbiology · 2025
    Article
  15. mBio · 2024
    Article
  16. Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Review
  19. Review
  20. Infection and immunity · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Kavita AgarwalDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6472-0731
Biswa ChoudhuryGlycobiology Research and Training Center, UCSD, La Jolla, CA 92093, USA.
Lloyd S RobinsonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sydney R MorrillDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5211-7524
Yasmine BouchibitiDepartment of Chemistry, University of California Davis, Davis, CA 95616, USA.
Daisy Chilin-FuentesCenter for Computational Biology and Bioinformatics, UCSD, La Jolla, CA 92093, USA.
Sara B RosenthalCenter for Computational Biology and Bioinformatics, UCSD, La Jolla, CA 92093, USA.ORCID 0000-0002-6548-9658
Kathleen M FischDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego (UCSD), La Jolla, CA 92093, USA.ORCID 0000-0002-0117-7444
Jeffrey F PeipertDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8546-1943
Carlito B LebrillaDepartment of Chemistry, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0001-7190-5323
Jenifer E AllsworthDepartment of Biomedical and Health Informatics, University of Missouri, Kansas City School of Medicine, Kansas City, MO 64110, USA.
Amanda L LewisDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6195-3030
Warren G LewisDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1210-6403
Washington University in St. Louis · USUniversity of California San Diego · USUniversity of California, Davis · USIndiana University School of MedicineUniversity of Missouri–Kansas City · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
ROLES OF SIALIDASE IN G. VAGINALIS-HOST INTERACTIONS DURING BACTERIAL VAGINOSISR01AI114635 · NIAID · WASHINGTON UNIVERSITY · PI LEWIS, AMANDA L., LEWIS, WARREN G · 2015 to 2025
$5.9M
Glycogen in Bacterial Vaginosis & How Carbohydrates Shape the Vaginal MicrobiomeR01AI127554 · NIAID · WASHINGTON UNIVERSITY · PI LEWIS, WARREN G · 2017 to 2021
$1.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS R01 AI114635NIAID NIH HHS R01 AI127554NIH HHS S10 OD026929ODCDC CDC HHS S10 OD026929
6 · The paper itself

Abstract

Epithelial cells are covered in carbohydrates (glycans). This glycan coat or "glycocalyx" interfaces directly with microbes, providing a protective barrier against potential pathogens. Bacterial vaginosis (BV) is a condition associated with adverse health outcomes in which bacteria reside in direct proximity to the vaginal epithelium. Some of these bacteria, including

Indexed as

Gardnerella vaginalisVaginosis, BacterialBacteriaFemaleHumansNeuraminidasePolysaccharidesVaginaNeuraminidasePolysaccharides

Identifiers

PMID38019934
PMCPMC11419735
OpenAlexW4389127809

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.