ArticleThe Plant cell2024
The transcription factor MdBPC2 alters apple growth and promotes dwarfing by regulating auxin biosynthesis.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 37 citations in OpenAlex.
- A VLCFA-auxin regulatory module modulates root morphogenesis in apple.Horticulture research · 2026Article
- The Transcription Factor PsLBD42 Enhances Drought Tolerance Through Regulating the Fucosyltransferase PsFUT2 to Sustain Root Growth in Poplar.Plant, cell & environment · 2026Article
- Isolation and Identification of an Endophytic FungusMicroorganisms · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Characterization of the BPC genes in alfalfa and functional verification of MsBPC10 in salt tolerance.BMC plant biology · 2026Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2026Article
- Light regulates tomato fruit metabolome via SlDML2-mediated global DNA demethylation.Journal of integrative plant biology · 2026Article
- Root-Specific Signal Modules Mediating Abiotic Stress Tolerance in Fruit Crops.Plants (Basel, Switzerland) · 2026Review
- Acceleration of flowering in woody plants by grafting.Plant cell reports · 2026Review
- Identification and expression analysis of apple CYP family genes in different rootstock-scion combination.BMC plant biology · 2025Article
- A novel role of BPCs in the control of medial domain differentiation during gynoecium development in Arabidopsis thaliana.Plant molecular biology · 2025Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Genome-wide identification of the WIP family in foxtail millet (Setaria italica) and functional analysis of SiWIP3 in inhibiting growth in transgenic Arabidopsis thaliana.BMC genomics · 2025Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2025Article
- The Transcription Factor Basic Pentacysteine 5, RsBPC5, Enhances Lead Stress Tolerance inPlants (Basel, Switzerland) · 2025Article
- Genome-wide characterization of BPC transcription factors in pear and functional validation ofFrontiers in plant science · 2025Article
- Integrated physiological, transcriptomic, and metabolomic analyses ofFrontiers in plant science · 2025Article
- PpGATA21 Enhances the Expression ofInternational journal of molecular sciences · 2024Article
- An apple a day: MdBPC2 transcription factor keeps the auxin away and causes dwarfing in Malus domestica.The Plant cell · 2024Article
- Genome-wide identification and characterization of BASIC PENTACYSTEINE transcription factors and their binding motifs in coconut palm.Frontiers in plant science · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Auxin plays important roles throughout plant growth and development. However, the mechanisms of auxin regulation of plant structure are poorly understood. In this study, we identified a transcription factor (TF) of the BARLEY B RECOMBINANT/BASIC PENTACYSTEINE (BBR/BPC) family in apple (Malus × domestica), MdBPC2. It was highly expressed in dwarfing rootstocks, and it negatively regulated auxin biosynthesis. Overexpression of MdBPC2 in apple decreased plant height, altered leaf morphology, and inhibited root system development. These phenotypes were due to reduced auxin levels and were restored reversed after exogenous indole acetic acid (IAA) treatment. Silencing of MdBPC2 alone had no obvious phenotypic effect, while silencing both Class I and Class II BPCs in apple significantly increased auxin content in plants. Biochemical analysis demonstrated that MdBPC2 directly bound to the GAGA-rich element in the promoters of the auxin synthesis genes MdYUC2a and MdYUC6b, inhibiting their transcription and reducing auxin accumulation in MdBPC2 overexpression lines. Further studies established that MdBPC2 interacted with the polycomb group (PcG) protein LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) to inhibit MdYUC2a and MdYUC6b expression via methylation of histone 3 lysine 27 (H3K27me3). Silencing MdLHP1 reversed the negative effect of MdBPC2 on auxin accumulation. Our results reveal a dwarfing mechanism in perennial woody plants involving control of auxin biosynthesis by a BPC transcription factor, suggesting its use for genetic improvement of apple rootstock.
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