Evidence map›Paper›PMID 38019855›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Expression of the vesicular GABA transporter within neuromedin S

Ivana L Bussi, Alexandra F Neitz, Raymond E A Sanchez, Leandro P Casiraghi, Michael Moldavan, Divya Kunda, Charles N Allen, Jennifer A Evans, Horacio O de la Iglesia

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ivana L BussiDepartment of Biology, University of Washington, Seattle, WA 98195-1800.
Alexandra F NeitzDepartment of Biology, University of Washington, Seattle, WA 98195-1800.ORCID 0000-0002-5717-0436
Raymond E A SanchezDepartment of Biology, University of Washington, Seattle, WA 98195-1800.
Leandro P CasiraghiDepartment of Biology, University of Washington, Seattle, WA 98195-1800.ORCID 0000-0002-1528-1402
Michael MoldavanOregon Institute for Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0003-4039-0325
Divya KundaDepartment of Biology, University of Washington, Seattle, WA 98195-1800.
Charles N AllenOregon Institute for Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239.ORCID 0000-0002-3689-2878
Jennifer A EvansDepartment of Biomedical Sciences, Marquette University, Milwaukee, WI 53233.ORCID 0000-0002-6220-0273
Horacio O de la IglesiaDepartment of Biology, University of Washington, Seattle, WA 98195-1800.ORCID 0000-0003-0855-6807
University of Washington · USOregon Health & Science University · USMarquette University · US

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
VISUAL SCIENCES TRAINING PROGRAMT32EY007031 · NEI · UNIVERSITY OF WASHINGTON · PI Wyeth Daniel Bair, Anitha Pasupathy · 1985 to 2026
$6.1M
Mechanisms of GABAergic Signaling in the Suprachiasmatic Nucleus NetworkR01NS103842 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLEN, CHARLES N · 2018 to 2025
$4.0M
Sleep in fear-entrained miceR01NS110012 · NINDS · UNIVERSITY OF WASHINGTON · PI DE LA IGLESIA, HORACIO O, KIM, JEANSOK JOHN · 2019 to 2023
$1.8M
Sexual dimorphic circuits in photoperiodic encoding and photic processingR01GM143545 · NIGMS · MARQUETTE UNIVERSITY · PI EVANS, JENNIFER ANNE, SAVTCHOUK, IAROSLAV · 2022 to 2025
$1.6M
Role of GABA on circadian and homeostatic regulation of sleepR01NS094211 · NINDS · UNIVERSITY OF WASHINGTON · PI DE LA IGLESIA, HORACIO O · 2015 to 2018
$1.4M
Non-pharmacological intervention to ameliorate epilepsy and its comorbiditiesR03NS103111 · NINDS · UNIVERSITY OF WASHINGTON · PI DE LA IGLESIA, HORACIO O · 2018 to 2019
$156k
REGULATION OF THE OUTER BLOOD-RETINAL BARRIERF32EY007031 · NEI · YALE UNIVERSITY · PI WILT, STEVEN D · 1999 to 2000
$11k
NEI NIH HHS F32 EY007031NEI NIH HHS P30 EY001730NEI NIH HHS T32 EY007031NIGMS NIH HHS R01 GM143545NINDS NIH HHS R01 NS094211NINDS NIH HHS R01 NS103842NINDS NIH HHS R01 NS110012NINDS NIH HHS R03 NS103111
6 · The paper itself

Abstract

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of a central circadian clock that orchestrates overt rhythms of physiology and behavior. Circadian timekeeping requires intercellular communication among SCN neurons, and multiple signaling pathways contribute to SCN network coupling. Gamma-aminobutyric acid (GABA) is produced by virtually all SCN neurons, and previous work demonstrates that this transmitter regulates coupling in the adult SCN but is not essential for the nucleus to sustain overt circadian rhythms. Here, we show that the deletion of the gene that codes for the GABA vesicular transporter

Indexed as

Circadian ClocksCircadian RhythmArrhythmias, Cardiacgamma-Aminobutyric AcidHumansNeuronsSuprachiasmatic NucleusVasoactive Intestinal PeptideVesicular Inhibitory Amino Acid Transport Proteinsgamma-Aminobutyric AcidVasoactive Intestinal Peptidevesicular GABA transporterVesicular Inhibitory Amino Acid Transport ProteinsGABAsleepsuprachiasmaticVgat

Identifiers

PMID38019855
PMCPMC10710084
OpenAlexW4389128645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.