Evidence map›Paper›PMID 38019246›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Prognostic Value of Immunohistochemical Expression of MTAP and AKIP1 in IDH1 Mutant Astrocytoma.

Mona Mostafa Ahmed, Mohammed A Lateef, Amira Elwan, Enas M Fouad, Dalia Hamouda Elsayed, Hanim M Abdelnour, Asmaa Abdullatif

Open access · goldAbstract read
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Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mona Mostafa AhmedDepartment of Pathology, Faculty of Medicine, Zagazig University, Egypt.
Mohammed A LateefDepartment of Neurosurgery, Faculty of Medicine, Zagazig University, Egypt.
Amira ElwanDepartment of Clinical Oncology, Faculty of Medicine, Zagazig University, Egypt.
Enas M FouadDepartment of Pathology, Faculty of Medicine, Zagazig University, Egypt.
Dalia Hamouda ElsayedDepartment of Medical Oncology, Faculty of Medicine, Zagazig University, Egypt.
Hanim M AbdelnourDepartments of Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
Asmaa AbdullatifDepartment of Pathology, Faculty of Medicine, Zagazig University, Egypt.
Zagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDefinite treatment for glioma is not exist, and with increased drug resistance, more effort should be paid to identify new prognostic biomarkers and molecular targets for therapy for glioma patients.

aimThe current study aimed to evaluate the immunohistochemical (IHC) expression of MTAP and A-Kinase Interacting Protein 1 (AKIP1) in astrocytoma and to investigate their association with the clinicopathological characters of these cases.

methodsTotally 66 cases of astrocytoma patients involved in this study. Cases underwent tumor resection and tissue sections were stained with MTAP, AKIP1 and IDH1 by IHC and evaluated in different grades of astrocytoma and their association with survival and response to therapy was investigated.

resultsHigh AKIP1 expression was positively correlated with treatment resistance and progressive disease. Positive IDH and retained MTAP expressions had shown better treatment response rather than negative IDH and lost MTAP. High AKIP, negative IDH and loss of MTAP expressions were significantly associated with poor survival outcome.

conclusionIrrespective to grade and IDH status, the loss of MTAP immunoreactivity and high AKIP1 expression are predictive factors in astrocytoma, and they may be used as a biomarker for guiding astrocytoma management and prognosis surveillance.

Indexed as

AstrocytomaGliomaAdaptor Proteins, Signal TransducingHumansIsocitrate DehydrogenaseNuclear ProteinsPrognosisAdaptor Proteins, Signal TransducingAKIP1 protein, humanIDH1 protein, humanIsocitrate DehydrogenaseNuclear ProteinsAKIP1astrocytomaIsocitrate dehydrogenase1MTAPsurvival

Identifiers

PMID38019246
PMCPMC10772751
OpenAlexW4389139356

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