Evidence map›Paper›PMID 38018983›Full record

ArticleMicrobiology spectrum2024

Healthy diet intervention reverses the progression of NASH through gut microbiota modulation.

Suraphan Panyod, Wei-Kai Wu, Meng-Yun Hu, Huai-Syuan Huang, Rou-An Chen, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Endoscopic sleeve gastrectomyWorld journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Suraphan Panyod *Institute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.ORCID 0000-0001-8998-375X
Wei-Kai Wu *Department of Medical Research, National Taiwan University Hospital , Taipei, Taiwan.
Meng-Yun HuInstitute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
Huai-Syuan HuangInstitute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
Rou-An ChenInstitute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
Yi-Hsun ChenDepartment of Internal Medicine, College of Medicine, National Taiwan University , Taipei, Taiwan.
Ting-Chin David ShenDivision of Gastroenterology, University of Pennsylvania, Perelman School of Medicine , Philadelphia, Pennsylvania, USA.
Chi-Tang HoDepartment of Food Science, Rutgers University , New Brunswick, New Jersey, USA.
Chun-Jen LiuDepartment of Internal Medicine, College of Medicine, National Taiwan University , Taipei, Taiwan.
Hsiao-Li ChuangNational Laboratory Animal Center, National Applied Research Laboratories , Taipei, Taiwan.
Chi-Chang HuangGraduate Institute of Sports Science, National Taiwan Sport University , Taoyuan City, Taiwan.
Ming-Shiang WuDepartment of Internal Medicine, College of Medicine, National Taiwan University , Taipei, Taiwan.ORCID 0000-0002-1940-6428
Lee-Yan SheenInstitute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.ORCID 0000-0001-5541-652X
National Taiwan University · TWNational Institutes of Applied Research · TWNational Taiwan Sport University · TWNational Taiwan University Hospital · TWRutgers, The State University of New Jersey · USUniversity of Pennsylvania · US

Funding

Ministry of Science and Technology, Taiwan (MOST) 109-2314-B-002-064-MY3, 111-2628-B-002-047Ministry of Science and Technology, Taiwan (MOST) 109-2327-B-002-005, 109-2314-B-002-103-MY3, 110-2327-B-002-007, 111-2327-B-002-008National Science and Technology Council (NSTC) 112-2327-B-002-009
6 · The paper itself

Abstract

importanceThe link between gut microbiota and diet is crucial in the development of non-alcoholic steatohepatitis (NASH). This study underscores the essential role of a healthy diet in preventing and treating NASH by reversing obesity, lipidemia, and gut microbiota dysbiosis. Moreover, the supplementation of functional food or drug to the diet can provide additional advantages by inhibiting hepatic inflammation through the modulation of the hepatic inflammasome signaling pathway and partially mediating the gut microbiota and lipopolysaccharide signaling pathway. This study highlights the importance of adopting healthy dietary habits in treating NASH and proposes that supplementing with ginger essential oil or obeticholic acid may offer additional benefits. Nonetheless, further clinical studies are necessary to validate these findings.

Indexed as

Gastrointestinal MicrobiomeNon-alcoholic Fatty Liver DiseaseDiet, HealthyDiet, High-FatHumansLiverGAN dietginger essential oilgut microbiomeinflammasomeLPSnon-alcoholic steatohepatitisobeticholic acid

Identifiers

PMID38018983
PMCPMC10782987
OpenAlexW4389136707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.