Evidence map›Paper›PMID 38018962›Full record

ArticleAntimicrobial agents and chemotherapy2024

Repurposing a human acetyl-CoA carboxylase inhibitor firsocostat to treat fungal candidiasis alone and in combination.

Tianyu Chen, Jing Yao, Keao Quan, Jingchen Xu, Xudong Hang, Qian Tong, Genyan Liu, Peipei Luo, Liping Zeng, Ganzhu Feng and 1 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Tianyu ChenDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Jing YaoDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Keao QuanDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Jingchen XuDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Xudong HangDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Qian TongDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Genyan LiuDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu, China.
Peipei LuoDepartment of Gastroenterology, Wujin People's Hospital Affiliated to Jiangsu University , Changzhou, Jiangsu, China.
Liping ZengDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.
Ganzhu FengDepartment of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University , Nanjing, Jiangsu, China.ORCID 0000-0003-3926-1753
Hongkai BiDepartment of Pathogen Biology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University , Nanjing, Jiangsu, China.ORCID 0000-0003-0085-6602
Nanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNJiangsu Province Hospital · CNJiangsu University · CNNantong University · CN

Funding

The Changzhou Science and Technology Project Fund CJ20210012The Hospital-level Foundation of the Affiliated Taizhou People's Hospital of Nanjing Medical University ZL202206The National Key Research and Research Development Programs of China 2018YFC0311003The National Natural Science Founadation of China 82073899
6 · The paper itself

Abstract

Opportunistic fungal infections, particularly caused by

Indexed as

Antifungal AgentsCandidiasisAcetyl-CoA CarboxylaseAnimalsCandida albicansDrug RepositioningDrug Resistance, FungalFluconazoleHumansIsobutyratesMiceMicrobial Sensitivity TestsOxazolesPyrimidinesAcetyl-CoA CarboxylaseAntifungal AgentsfirsocostatFluconazoleIsobutyratesOxazolesPyrimidinesacetyl-CoA carboxylaseCandida albicansfirsocostatsynergyvoriconazole

Identifiers

PMID38018962
PMCPMC10777831
OpenAlexW4389137000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.