ArticleStroke2024
Dental Caries, Race and Incident Ischemic Stroke, Coronary Heart Disease, and Death.
Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Oral Health Status And Oral Health Related Quality of Life in Children With Congenital Heart Disease-A Systematic Review And Meta-Analysis.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryPooled it
- Implementation of stroke prevention: a review of challenges and opportunities in the Americas.Lancet regional health. Americas · 2026Review
- Research priorities for oral health in people with severe mental ill-health.BMJ mental health · 2026Article
- Observational
- Dental caries prevalence and associated factors among schoolchildren aged 6-8 years in Macao: a cross-sectional study (2015-2020).BMC oral health · 2026Article
- Association between dental caries and self-reported COPD prevalence in U.S. adults ages ≥ 60-year: a cross-sectional analysis of NHANES 2015-2020.Journal of oral microbiology · 2026Article
- Associations Between Single and Multiple Vitamins and the Risk of Dental Caries: Results from a Cross-Sectional Study and Mendelian Randomisation Analysis.Oral health & preventive dentistry · 2025Article
- Article
- Combined Influence of Dental Caries and Periodontal Disease on Ischemic Stroke Risk.Neurology open access · 2025Article
- Dental Caries Status and Associated Factors Among Adults in Southeastern Iran: Findings From the Zahedan Adult Cohort Study.Clinical and experimental dental research · 2025Article
- Burden and Predictions of Untreated Caries in China, 1990-2039: A Systematic Analysis for the Global Burden of Disease Study 2019.Clinical and experimental dental research · 2025Article
- The Missing Piece in Chronic Disease Prevention: Dental Caries.Preventing chronic disease · 2025Article
- Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al.European heart journal · 2025Article
- Association Between Multimorbidity and Root Caries Among Older American Adults.Dentistry journal · 2025Article
- Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025Review
- The oral microbiome and atherosclerosis: current evidence on association, mechanisms, and clinical implications.Frontiers in immunology · 2025Review
- The screening assessment of pro-inflammatory, anti-inflammatory, Th1, Th2 and Th17 cytokines in saliva of patients with ischemic stroke.International journal of medical sciences · 2025Article
- Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review.Microorganisms · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundDental caries is a highly prevalent disease worldwide. In the United States, untreated dental caries is present in >1 in 5 adults. The objective of this study was to determine the relationship between dental caries and incident ischemic stroke, coronary heart disease (CHD) events, and death.
methodsThe dental cohort (n=6351) of the ARIC study (Atherosclerosis Risk in Communities) was followed for incident ischemic stroke, CHD event, and all-cause mortality. Of all the participants at visit 4 (n=11 656), those who were unable to go through dental examination, or with prevalent ischemic stroke and CHD events, were excluded. The full-mouth dental examination was conducted at visit 4 (1996-1998), assessing dental caries. The dose response of decayed, missing, and filled surfaces due to caries was assessed and related to the outcome. Outcomes were assessed through the end of 2019. Additionally, the effect of regular dental care utilization on dental caries was evaluated.
resultsParticipants with ≥1 dental caries had an increased risk of stroke (adjusted hazard ratio [HR], 1.40 [95% CI, 1.10-1.79]) and death (adjusted HR, 1.13 [95% CI, 1.01-1.26]) but not for CHD events (adjusted HR, 1.13 [95% CI, 0.93-1.37]). The association of dental caries and ischemic incident stroke was significantly higher in the African American population compared with the White subgroup (interaction term
conclusionsAmong the cohort, dental caries was independently associated with the risk of ischemic stroke and death, with the effect higher in African American participants. Regular dental care utilization was associated with a lower chance of caries, emphasizing its relevance in the prevention of these events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.