Evidence map›Paper›PMID 38018559›Full record

ArticleCNS neuroscience & therapeutics2024

A neural circuit associated with anxiety-like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture.

Zemin Wu, Zui Shen, Yingling Xu, Shaozong Chen, Siqi Xiao, Jiayu Ye, Haiyan Zhang, Xinyi Ma, Yichen Zhu, Xixiao Zhu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Zemin WuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-9534-8725
Zui ShenKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Yingling XuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0009-0008-8335-4715
Shaozong ChenInstitution of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China.
Siqi XiaoKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Jiayu YeKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Haiyan ZhangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xinyi MaKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Yichen ZhuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xixiao ZhuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Yongliang JiangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Junfan FangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Boyi LiuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Xiaofen HeKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Shuzhong GaoInstitution of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xiaomei ShaoKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Jinggen LiuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Jianqiao FangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
The Third Affiliated Hospital of Zhejiang Chinese Medical University · CNZhejiang Chinese Medical University · CNShandong University of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China 82074518National Natural Science Foundation of China 82074541National Natural Science Foundation of China 82274635Zhejiang Provincial Natural Science Foundation of China LY21H270010
6 · The paper itself

Abstract

aimsNegative emotions induced by chronic pain are a serious clinical problem. Electroacupuncture (EA) is a clinically proven safe and effective method to manage pain-related negative emotions. However, the circuit mechanisms underlying the effect of EA treatment on negative emotions remain unclear.

methodsPlantar injection of complete Freund's adjuvant (CFA) was performed to establish a rat model of chronic inflammatory pain-induced anxiety-like behaviors. Adeno-associated virus (AAV) tracing was used to identify excitatory synaptic transmission from the rostral anterior cingulate cortex (rACC) to the dorsal raphe nucleus (DRN). Employing chemogenetic approaches, we examined the role of the rACC-DRN circuit in chronic pain-induced anxiety-like behaviors and investigated whether EA could reverse chronic pain-induced dysfunctions of the rACC-DRN circuit and anxiety-like behaviors.

resultsWe found that chemogenetic activation of the rACC-DRN circuit alleviated CFA-induced anxiety-like behaviors, while chemogenetic inhibition of the rACC-DRN circuit resulted in short-term CFA-induced anxiety-like behaviors. Further research revealed that the development of CFA-induced anxiety-like behaviors was attributed to the dysfunction of rACC CaMKII neurons projecting to DRN serotonergic neurons (rACC

conclusionsOur data suggest that the reversal of rACC

Indexed as

Anti-Anxiety AgentsChronic PainElectroacupunctureAnimalsAnxietyCalcium-Calmodulin-Dependent Protein Kinase Type 2gamma-Aminobutyric AcidRatsSerotonergic NeuronsSerotoninAnti-Anxiety AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2gamma-Aminobutyric AcidSerotoninanxiety‐like behaviorchronic inflammatory paindorsal raphe nucleuselectroacupuncturerostral anterior cingulate cortexserotonergic neurons

Identifiers

PMID38018559
PMCPMC11017463
OpenAlexW4389141928

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.