Evidence map›Paper›PMID 38018492›Full record

ArticleJournal of the American Heart Association2023

Association Between Onset Age of Coronary Heart Disease and Incident Dementia: A Prospective Cohort Study.

Jie Liang, Chenglong Li, Darui Gao, Qian Ma, Yongqian Wang, Yang Pan, Wenya Zhang, Wuxiang Xie, Fanfan Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jie LiangDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Chenglong LiHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing China.ORCID 0000-0003-1970-3358
Darui GaoHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing China.
Qian MaDepartment of Cardiology, Beijing Anzhen Hospital Capital Medical University Beijing China.
Yongqian WangHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing China.
Yang PanDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Wenya ZhangDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.
Wuxiang XieHeart and Vascular Health Research Center Peking University Clinical Research Institute, Peking University First Hospital Beijing China.ORCID 0000-0001-7527-1022
Fanfan ZhengDepartment of Clinical Nursing, School of Nursing Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.ORCID 0000-0003-2767-2600
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking University · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of age at coronary heart disease (CHD) onset with incident dementia remains unexplored. This study aimed to examine whether younger onset age of CHD is associated with a higher risk of incident dementia. METHODS AND

resultsData were obtained from the UK Biobank. Information on the diagnosis of CHD and dementia was collected at baseline and follow-ups. Propensity score matching method and Cox proportional hazards models were used to evaluate the association between different ages at CHD onset and incident dementia. A total of 432 667 adults (mean±SD age, 56.9±8.1 years) were included, of whom 11.7% had CHD. Compared with participants without CHD, participants with CHD exhibited higher risks of developing all-cause dementia, Alzheimer's disease, and vascular dementia. More importantly, younger age at CHD onset (per 10-year decrease) was significantly associated with elevated risks of all-cause dementia (hazard ratio [HR], 1.25 [95% CI, 1.20-1.30];

conclusionsYounger onset age of CHD is associated with higher risks of incident all-cause dementia, Alzheimer's disease, and vascular dementia, underscoring the necessity to pay attention to the neurocognitive status of individuals diagnosed with CHD at younger age to conduct timely interventions to attenuate subsequent risk of incident dementia.

Indexed as

Alzheimer DiseaseCoronary DiseaseDementia, VascularMyocardial InfarctionAdultAgedAge of OnsetHumansMiddle AgedProspective StudiesRisk Factorscoronary heart diseasedementiaonset agepropensity score matchingUK Biobank

Identifiers

PMID38018492
PMCPMC10727352
OpenAlexW4389142626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.