Evidence map›Paper›PMID 38018439›Full record

ArticleCirculation. Arrhythmia and electrophysiology2023

Risk Factors for the Development of New-Onset Persistent Atrial Fibrillation: Subanalysis of the VITAL Study.

Melissa E Middeldorp, Roopinder K Sandhu, Jessica Mao, Baris Gencer, Jacqueline S Danik, Vinayaga Moorthy, Nancy R Cook, Christine M Albert

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02178410 (Vitamin D and Omega-3 Trial), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02178410 phase3active not recruitingnot on this map

Vitamin D and Omega-3 Trial (VITAL Rhythm Study)

TypeinterventionalSponsorBrigham and Women's HospitalRan2012 to 2026Enrolled25,119ConditionsCardiovascular DiseaseArmsVitamin D3, Omega-3 fatty acids (fish oil), Fish oil placebo, Vitamin D3 placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Melissa E MiddeldorpDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (M.E.M., R.K.S., J.M., C.M.A.).ORCID 0000-0002-4106-9771
Roopinder K SandhuDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (M.E.M., R.K.S., J.M., C.M.A.).ORCID 0000-0002-2629-3476
Jessica MaoDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (M.E.M., R.K.S., J.M., C.M.A.).
Baris GencerCardiology Division, Geneva University Hospitals, Switzerland (B.G.).ORCID 0000-0002-8954-9694
Jacqueline S DanikDivision of Cardiovascular Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston. (J.S.D.).
Vinayaga MoorthyHarvard Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston. (V.M., N.R.C.).
Nancy R CookHarvard Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston. (V.M., N.R.C.).ORCID 0000-0002-9705-0842
Christine M AlbertDepartment of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA (M.E.M., R.K.S., J.M., C.M.A.).ORCID 0000-0002-2081-1121
Cedars-Sinai Smidt Heart Institute · USBrigham and Women's Hospital · USBern University of Applied Sciences · CHHarvard University · US

Funding

VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
The VITAL Rhythm StudyR01HL116690 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALBERT, CHRISTINE M · 2013 to 2020
$3.5M
NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NHLBI NIH HHS R01 HL116690
6 · The paper itself

Abstract

backgroundSustained forms of atrial fibrillation (AF) are associated with lower treatment success rates and poorer prognosis compared with paroxysmal AF. Yet, little is known about risk factors that predispose to persistent AF on initial presentation. Our objective was to define risk factors associated with new-onset persistent AF.

methodsWe prospectively examined the differential associations between lifestyle, clinical, and socioeconomic risk factors and AF pattern (persistent versus paroxysmal) at the time of diagnosis among 25 119 participants without a history of cardiovascular disease, AF, or cancer in the VITAL rhythm study (Vitamin D and Omega-3).

resultsDuring a median follow-up of 5.3 years, 900 participants developed AF and 346 (38.4%) were classified as persistent at the time of diagnosis. In multivariable competing risk models, increasing age, male sex, White race, height, weight, body mass index ≥30 kg/m

conclusionsIn a prospective cohort without baseline AF or cardiovascular disease, over one-third of AF at the time of diagnosis is persistent. Older age, male sex, postcollege education, and obesity were preferentially associated with persistent AF and represent a high-risk AF subset for population-based intervention.

Indexed as

Atrial FibrillationFemaleHumansMaleObesityProspective StudiesRandomized Controlled Trials as TopicRisk FactorsVitamin DVitamin Darrhythmiasatrial fibrillationcardiovascular diseaseslifestylerisk factors

Identifiers

PMID38018439
PMCPMC10852030
OpenAlexW4389143207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.