ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging
Paramagnetic rim lesions and the central vein sign: Characterizing multiple sclerosis imaging markers.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Central Vein Sign and Paramagnetic Rim Lesions in Patients with Relapsing-Remitting Multiple Sclerosis: An Assessment of Prevalence and Anatomical Location.Neurology international · 2026Article
- The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study.Annals of clinical and translational neurology · 2025Article
- Updates in Multiple Sclerosis Imaging.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Review
- Frequency and Diagnostic Implications of Paramagnetic Rim Lesions in People Presenting for Diagnosis to a Multiple Sclerosis Clinic.Neurology · 2025Observational
- Paramagnetic rim lesions in early multiple sclerosis: a 7 Tesla imaging study.Brain communications · 2025Article
- How to Implement Clinical 7T MRI-Practical Considerations and Experience with Ultra-High-Field MRI.Bioengineering (Basel, Switzerland) · 2024Article
- Chronic active lesions preferentially localize in watershed territories in multiple sclerosis.Annals of clinical and translational neurology · 2024Article
- The influence of MOGAD on diagnosis of multiple sclerosis using MRI.Nature reviews. Neurology · 2024Review
- The central vein sign and paramagnetic rim lesions: biomarkers for an accurate differential diagnosis between multiple sclerosis and migraine.Radiologia brasileiraArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeParamagnetic rims and the central vein sign (CVS) are proposed imaging markers of multiple sclerosis (MS) lesions. Using 7 tesla magnetic resonance imaging, we aimed to: (1) characterize the appearance of paramagnetic rim lesions (PRLs); (2) assess whether PRLs and the CVS are associated with higher levels of MS pathology; and (3) compare the characteristics between subjects with and without PRLs in early MS.
methodsProspective study of 32 treatment-naïve subjects around the time of diagnosis who were assessed for the presence of PRLs and the CVS. Comparisons of lesion volume and macromolecular pool size ratio (PSR) index, a proxy of myelin integrity, between PRLs and non-PRLs, and CVS-positive and CVS-negative lesions were carried out. Differences in clinical/demographic characteristics between patients with PRLs and those without were tested.
resultsFifteen subjects had ≥1 PRL for a total of 36 PRLs, of which two-thirds had a full rim. PRLs predicted a larger lesion size and decreased PSR signal. Lesion volume and presence of cervical spine lesions were significantly different between subjects with PRLs and those without, although neither remained significant after adjusting for multiple comparisons. One hundred and eighty-one lesions with CVS were identified with no differences between CVS-positive and CVS-negative lesions in volume (p = .27) and PSR values (p = .62).
conclusionsPRLs, but not CVS-positive lesions, are larger and have lower myelin integrity. Our findings indicate that PRLs are associated with higher levels of lesion-specific pathology prior to the start of disease-modifying therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.