Evidence map›Paper›PMID 38017501›Full record

ArticleBMC pulmonary medicine2023

Using intra-breath oscillometry in obesity hypoventilation syndrome to detect tidal expiratory flow limitation: a potential marker to optimize CPAP therapy.

Szabolcs Baglyas, Luca Valkó, Vivien Móró, Eszter Podmaniczky, Dorottya Czövek, Gergely Makan, Zoltán Gingl, János Gál, Zoltán Hantos, András Lorx

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Szabolcs BaglyasDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary. baglyas.szabolcs@semmelweis.hu.
Luca ValkóDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
Vivien MóróDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
Eszter PodmaniczkyDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
Dorottya CzövekDepartment of Pediatrics, Semmelweis University, Budapest, Hungary.
Gergely MakanDepartment of Technical Informatics, University of Szeged, Szeged, Hungary.
Zoltán GinglDepartment of Technical Informatics, University of Szeged, Szeged, Hungary.
János GálDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
Zoltán HantosDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
András LorxDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 1082 Üllői út 78/B, Budapest, Hungary.
Semmelweis University · HUUniversity of Szeged · HU

Funding

European Respiratory Society Clinical Research Collaboration Award CRC_2013-02_INCIRCLEHungarian Scientific Research Fund FK 129237Hungarian Scientific Research Fund K 128701János Bolyai Research Scholarship of the Hungarian Academy of Sciences ÚNKP-19-4-SE-96
6 · The paper itself

Abstract

backgroundContinuous positive airway pressure (CPAP) therapy has profound effects in obesity hypoventilation syndrome (OHS). Current therapy initiation focuses on upper airway patency rather than the assessment of altered respiratory mechanics due to increased extrapulmonary mechanical load.

methodsWe aimed to examine the viability of intra-breath oscillometry in optimizing CPAP therapy for OHS. We performed intra-breath oscillometry at 10 Hz in the sitting and supine positions, followed by measurements at increasing CPAP levels (none-5-10-15-20 cmH

resultsThirty-five patients (65.7% male) completed the study. We found a characteristic looping of the Xrs vs V' plot in all patients in the supine position revealing tEFL: Xrs fell with decreasing flow at end-expiration. Intra-breath variables representing expiratory decrease of Xrs became more negative in the supine position [end-expiratory Xrs (mean ± SD): -1.9 ± 1.8 cmH

conclusionstEFL, worsened by the supine position, can be diminished by stepwise CPAP application in most patients. Intra-breath oscillometry is a viable method to detect tEFL during CPAP initiation in OHS patients and tEFL is a possible target for optimizing therapy in OHS patients.

Indexed as

Continuous Positive Airway PressureObesity Hypoventilation SyndromeExhalationFemaleHumansMaleOscillometryRespiratory MechanicsBody positionContinuous positive airway pressureExpiratory flow limitationObesity hypoventilation syndromeOscillometry

Identifiers

PMID38017501
PMCPMC10685591
OpenAlexW4389082387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.