Evidence map›Paper›PMID 38017491›Full record

ArticleBMC medical genomics2023

Screening of key genes in the pathogenesis of muscle atrophy in CKD-PEW children based on RNA sequencing.

Liang Ying, Jiang Yeping, Wang Hui, Zhou Nan, FuQian, Shen Ying

Open access · goldAbstract read
PubMed Full text at PMC Publisher
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Article in BMC medical genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Liang YingDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China.
Jiang YepingDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China.
Wang HuiDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China.
Zhou NanDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China.
FuQianDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China.
Shen YingDepartment 2 of Nephrology, Beijing Key Laboratory for Chronic Renal Disease and Blood Purification, Beijing Children's Hospital Affiliated to Capital Medical University, Key Laboratory of Major Diseases in Children, National Center for Children's Health, China, Beijing, 100045, China. shenying@bch.com.cn.
Beijing Children’s Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of children and is an important cause of poor prognosis. We are aiming to explore the pathogenesis of muscle wasting in CKD-PEW children.

methodsBlood samples of 32 children diagnosed with chronic kidney disease (CKD) and protein energy wasting (PEW) in our hospital from January 2016 to June 2021 were collected. RNA sequencing and bioinformatics analysis were performed.

resultsBased on GO (Gene Ontology) functional enrichment analysis, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis and differential gene expression analysis, a total of 25 CKD-PEW related genes were obtained including CRP, IL6, TNF, IL1B, CXCL8, IL12B, IL12A, IL18, IL1A, IL4, IL10, TGFB2, TGFB1, TGFB3, ADIPOQ, NAMPT, RETN, RETNLB, LEP, CD163, ICAM1, VCAM1, SELE, NF-κB1, NF-κB2. The most significantly differentially expressed gene was NF-κB2 (adjusted P = 2.81 × 10

conclusionsA variety of inflammatory factors are involved in the pathogenesis of CKD-PEW in children, and chronic inflammation may lead to the development of muscle atrophy in CKD-PEW. It is suggested for the first time that NF-κB is a key gene in the pathogenesis of muscle wasting in CKD-PEW children, and its increased expression may play an important role in the pathogenesis of muscle wasting in children with CKD-PEW.

Indexed as

Protein-Energy MalnutritionRenal Insufficiency, ChronicCachexiaChildHumansMuscular AtrophyNF-kappa B p52 SubunitRenal DialysisSequence Analysis, RNANF-kappa B p52 SubunitChronic kidney diseaseKey genesMuscle atrophyNF-κBProtein-energy wastingRNA sequencing

Identifiers

PMID38017491
PMCPMC10683124
OpenAlexW4389086694

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